Senior Scientist , tLNP Formulation

Overview

About Abb Vie
Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

About the Team
The Targeted Lipid Nanoparticle (tLNP) drug product development group within Abb Vie’s tLNP CMC team is committed to advancing clinical-stage tLNP assets from First-in-Human (FIH) through Phase 2. The team collaborates across biologics discovery, CMC partners, Clinical Operations, Regulatory Affairs, Quality Assurance, and external manufacturing to support development and commercialization of tLNP products. Key focus areas include establishing robust formulation and process development capabilities, leading critical CMC activities for pipeline programs, devising formulation development strategies, conducting stability evaluations, optimizing clinical in-use strategies, developing innovative product presentations, implementing stage-based quality risk management, and driving scientific initiatives to ensure the strong development of current and future tLNP programs.

We are seeking a Senior Scientist to lead key scientific initiatives and provide leadership in the development of early stage targeted Lipid Nanoparticle (tLNP) assets within Abb Vie’s pipeline. This role is responsible for designing, executing, and effectively communicating hypothesis-driven formulation and process development activities. The successful candidate will collaborate closely with analytical teams, process development groups, and subject matter experts across Abb Vie to advance research and development in the tLNP space.

• Assess tLNP liabilities under practical worst-case stress conditions to inform excipient selection and formulation screening strategies
• Design and execute comprehensive formulation screening studies, evaluating variables such as pH, buffer, antioxidants, surfactants, cryoprotectants, and other stabilizing excipients
• Lead process development, optimization, and robustness studies, with a focus on sterile fill-finish operations
• Facilitate scale-up, technology transfer, and manufacturing readiness in close collaboration with internal and external stakeholders
• Utilize statistical methods and Design of Experiments (DoE) to optimize formulations and process parameters
• Develop and communicate clinical in-use strategies for investigational products, including assessment of in-use stability for clinical-stage programs
• Plan and conduct experiments to evaluate innovative tLNP product presentations, such as lyophilized forms, spray-dried powders, nonaqueous suspensions, and other advanced formats
• Interpret and present critical data, key findings, and recommendations in both internal and cross-functional team forums
• Maintain high laboratory productivity while ensuring strict adherence to corporate safety, quality, and good research practices
• Practice robust documentation standards by accurately recording experimental data, results, and conclusions in electronic lab notebooks, technical reports, and scientific presentations

Required

• PhD in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, Biotechnology, or a related field (0+ years industry experience); or MS with 6+ years of relevant industry experience
• Comprehensive theoretical knowledge of ICH regulations governing drug product formulation and sterile process development
• Proven…