Scientist, Analytical Technical Operations

The Moderna Analytical Technical Operations (ATO) team is seeking a Scientist to lead operational method development and enable the transition of analytical methods from development into robust, scalable, and high-throughput laboratory execution. This is an onsite role based at Moderna’s Technology Center campus in Norwood, MA.

You will serve as a critical scientific interface between Analytical Development and ATO, combining technical expertise in LC/MS, chromatography, microfluidic methods, automation, and high-throughput methodologies with a strong understanding of sample demand, turnaround time, equipment capacity, data flow, and routine execution requirements. You will drive method optimization, technology transfer, troubleshooting, and lifecycle improvements supporting characterization, in-process, release, and stability testing across Moderna programs.

Lead operational method development focused on robustness, reproducibility, throughput, automation compatibility, data integrity, and long-term sustainability.

Translate Analytical Development methods into standardized and scalable workflows suitable for routine, high-volume testing environments while preserving scientific intent and required performance.

Design and execute method studies supporting optimization, performance characterization, comparability, pre-validation, transfer, and operational readiness.

Provide technical expertise in LC/MS and separation sciences including HPLC/UHPLC, capillary electrophoresis, microfluidic platforms, method execution, data interpretation, and troubleshooting.

Advance microfluidic analytical methods including Lab Chip or comparable platforms, to improve speed, sample efficiency, consistency, and scalability.

Develop automation-ready workflows including sample preparation and analytical methods compatible with liquid handlers, robotic platforms, plate-based execution, and integrated data systems.

Apply high-throughput principles to optimize batching, instrument utilization, analyst touch time, cycle time, and overall laboratory capacity.

Serve as a primary scientific interface with Analytical Development by engaging early in method design and communicating operational requirements for volume, run time, controls, standards, equipment, data review, automation, and transferability.

Lead or support analytical technology transfer including transfer strategy, execution, acceptance criteria, knowledge transfer, training, documentation, and post-transfer monitoring.

Drive complex technical troubleshooting and investigations involving methods, instrumentation, reagents, samples, data, and workflow interactions using structured root cause analysis and experimental design.

Partner across Process Development, Formulation Sciences, Quality Control, Digital, Automation, Laboratory Engineering, and external organizations to ensure end-to-end method and technology readiness.

Create clear technical documentation including protocols, reports, transfer packages, work instructions, risk assessments, and training materials that enable consistent execution.

Mentor colleagues and strengthen organizational capability in method science, operational development, technology transfer, automation, and data-driven problem solving.

Drive continuous improvement and method lifecycle management through performance monitoring, modernization, change implementation, and sustainable corrective and preventive actions.

Education:

PhD in Analytical Chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences, Molecular Biology, or a related scientific discipline, or a Master’s or Bachelor’s degree with directly applicable industry experience.

Experience:

Demonstr…