Associate Principal Scientist - In Vivo Pharmacology

Ready to lead groundbreaking research that could transform the future of kidney disease treatment?

Proclinical is working alongside an internationally recognised drug discovery organisation who are seeking an experienced Associate Principal Scientist to provide scientific leadership across innovative preclinical discovery programmes focused on kidney disease, nephrology, chronic kidney disease, acute kidney injury, renal fibrosis and progressive renal disorders.

This is a senior scientific leadership opportunity for an experienced pharmacologist with expertise in renal disease biology and translational drug discovery. You will play a key role in advancing novel therapeutics from target validation through candidate selection while working closely with biotechnology and pharmaceutical partners developing next-generation treatments for kidney disease.

Working within multidisciplinary drug discovery teams, you will be responsible for the design, delivery, and interpretation of pharmacology studies supporting programmes across:

• Chronic Kidney Disease (CKD)

• Acute Kidney Injury (AKI)
• Diabetic Kidney Disease (DKD)
• Diabetic Nephropathy
• Renal Fibrosis
• Glomerular Disease
• Podocyte Biology
• Proteinuria
• Albuminuria
• Tubulointerstitial Fibrosis
• Kidney Inflammation
• Fibrotic Kidney Disorders
• Metabolic-Renal Disease
• Cardio-Renal Disease

You will contribute to target validation, mechanism-of-action studies, translational biomarker strategies and efficacy assessment, supporting progression of novel therapeutics into development.

• Lead and scientifically direct in vivo pharmacology programmes focused on renal and nephrology indications
• Design and oversee studies utilising relevant disease models of:
  • CKD
  • AKI
  • Renal Fibrosis
  • Diabetic Kidney Disease (DKD)
  • Proteinuric Kidney Disease
  • Glomerulonephritis
  • Nephropathy
  • Kidney Inflammation
  • Progressive Renal Disease
• Drive translational pharmacology strategies linking preclinical findings to clinical outcomes
• Support target validation and mechanism-of-action studies across pathways implicated in:
  • Fibrosis
  • Inflammation
  • Immune-Mediated Kidney Disease
  • Metabolic Dysfunction
  • Tissue Remodelling
  • Renal Injury and Repair
• Analyse and interpret efficacy, pharmacodynamic and biomarker data to guide programme decisions
• Collaborate with medicinal chemistry, DMPK, translational science, biomarker and safety teams
• Present scientific recommendations and project updates to external biotech and pharmaceutical clients
• Mentor scientists and contribute to the development of innovative in vivo and translational capabilities

• PhD in Pharmacology, Physiology, Nephrology, Biomedical Sciences or related discipline, or equivalent industry experience
• Significant experience in in vivo pharmacology within pharmaceutical, biotechnology or CRO-based drug discovery environments
• Strong expertise in renal disease biology and nephrology research
• Experience working within one or more of the following areas:
  • Chronic Kidney Disease (CKD)
  • Acute Kidney Injury (AKI)
  • Diabetic Kidney Disease (DKD)
  • Diabetic Nephropathy
  • Renal Fibrosis
  • Kidney Inflammation
  • Glomerular Disease
  • Proteinuria
  • Albuminuria
  • Podocyte Dysfunction
  • Tubular Injury
  • Fibrotic Disorders
• Proven ability to design, interpret and lead complex preclinical pharmacology studies
• Experience influencing scientific strategy and programme progression decisions
• Knowledge of UK regulations governing in vivo research
• Excellent communication and stakeholder engagement skills

• Expertise in translational nephrology
• Biomarker identification and validation
• Renal functional endpoints including:
  • eGFR
  • Albumin-Creatinine Ratio (ACR)
  • Urine Protein Biomarkers
  • Renal Histopathology
• Experience with pathways including:
  • TGF-? Signalling
  • Fibrotic Pathways
  • Inflammatory Cytokine Signalling
  • Complement Biology
  • Kidney Repair Mechanisms
  • Metabolic-Renal Pathways
• Client-facing scientific leadership within a CRO environment
• Project or line management experience

• Lead cutting-edge nephrology and renal drug discovery programmes
• Work on novel therapies targeting CKD, AKI, renal fibrosis and progressive kidney disease
• Influence strategic scientific decisions across multiple programmes
• Collaborate with leading biotech and pharmaceutical organisations
• Join a highly collaborative, research-driven environment with strong opportunities for scientific and leadership progression