Modelling & Simulation Research Fellow

Quotient Sciences:
Molecule to Cure. Fast.

Quotient Sciences is a leading drug development and manufacturing accelerator, helping biotech and pharma companies bring new medicines to patients faster. With over 35 years of experience and a track record of success, we provide Drug Product (CDMO) and Clinical (CRO) services across the entire development pathway, including formulation development, clinical pharmacology, clinical trials, and commercial product manufacturing.

Our proprietary and disruptive platform – “Translational Pharmaceutics®” – integrates Drug Product Manufacturing and Clinical Testing to eliminate silos in the drug development process. This in turn reduces costs
, improves outcomes, and significantly accelerates drug development times.

Because every day counts when bringing new medicines to patients. Our 1,000+ experts across the US, UK, and beyond are united by science, agility, and a culture that turns ideas into impact—fast.

This is a unique opportunity to become part of a passionate and collaborative team of PBPK modellers, dedicated to advancing drug development through cutting‑edge modelling and simulation. Our work spans an exciting spectrum—from first-in-human (FiH) pharmacokinetic and dose predictions, formulation risk assessments, and model‑informed formulation design in Translational Pharmaceutics® programmes, to virtual bioequivalence predictions for marketed drugs.

We are looking for curious, driven scientists who thrive on problem-solving and embrace continuous learning. We would prefer extensive experience with PBPK modelling, but we could consider candidates with strong backgrounds in DMPK, clinical pharmacology, or biopharmaceutics who have some hands‑on experience with PBPK models and are keen to develop their career in modelling.

• Build, test, and verify mechanistic PBPK/PBBM models to predict absorption and systemic exposure for small molecules, oral peptides, and other challenging modalities. You will perform sensitivity analyses and refine models to support decision‑making.
• Translate data into insight by linking in vitro DMPK/biopharm data and clinical results to model structures. You will design and interpret in vitro/in vivo studies in the context of ADME and formulation strategy.
• Advise on study design and formulation choices (e.g., enteric‑coated OSD, modified release, IVIVC, virtual bioequivalence, food/PPI effects) to de‑risk first‑in‑human and early clinical plans.
• Collaborate in integrated programmes leveraging our Translational Pharmaceutics® platform—connecting model predictions to real‑time clinical feedback to accelerate optimization.
• Client interactions:
  You will interpret and present expert conclusions from M&S work to Quotient and client project teams throughout the project life‑cycle.
• Authoring Reports:
  Produce high quality reports which clearly present and summarise M&S project findings.
• Support proposals and client engagement alongside Drug Development Consultants and BD, articulating the value of model‑informed development.
• You will critically review client data packages and prepare proposals for potential new M&S projects.

• Education:
  
  A minimum of a degree‑level qualification.
• Experience:
  
  You will have significant experience in biopharmaceutics, PK data analysis, PK modelling, DMPK and/or clinical pharmacology. You will be experienced in designing and interpreting scientific studies to address key objectives.
• Core expertise:
  You will have a strong track record of hands‑on building and applying PBPK models (ideally with Gastro Plus™), plus biopharmaceutics, PK data analysis, and clinical pharmacology expertise.
• Tools & platforms:
  You will be proficient with Gastro Plus™ and familiar with Simcyp®, PK‑Sim®, MoBi®, Phoenix/Win Nonlin.
• Applied impact:
  You will have practical experience predicting human PK from preclinical data, constructing bespoke compartmental absorption/PK models, and informing formulation decisions using in silico simulations.
• Communication:
  You will demonstrate excellent communication skills, with the ability to present clearly and…