Sr Scientist

Overview

Sr Scientist, Analytical Ops — United States - California - Oceanside. Process/Product Development & Operations. Regular

Gilead Sciences, Inc. is a research-based biopharmaceutical company founded in 1987. We deliver life-saving therapies to patients in need. Our mission requires collaboration, determination and a relentless drive to make a difference. We seek individuals to contribute to the discovery and development of life-changing scientific innovations and to help create possible, together.

We are looking for a candidate who will possess a detailed understanding of proteins and carbohydrates, and who is motivated to contribute to the research and development of biologics targeting unmet medical needs through biochemical characterization and novel method development supporting clinical and commercial programs. Experience in analytical chemistry, biochemistry, biological mass spectrometry, chromatography, enzymology, statistics, chemical and biophysical structural elucidation, and bioinformatics is strongly desired.

* At a future date this position will relocate to the corporate HQ in Foster City, CA.

• Support late-stage assay development by performing mass spectrometry to characterize molecules, degradation pathways, and define critical quality attributes in a phase-appropriate context.
• Contribute to analytical method development and qualification for protein characterization.
• Develop innovative assays to gain competitive advantages over standard industry practices.
• Support comparability and stability studies using mass spectrometry.
• Operate, maintain, and troubleshoot Waters, Sciex, Bruker QTOFs, and Thermo Orbitrap mass spectrometers.
• Solve complex problems requiring evaluation of intangible variables using logic, ingenuity, and creativity.
• Collaborate with junior and senior team members to advance state-of-the-art characterization techniques.
• Represent the Structure Characterization group in cross-functional project teams.
• Participate in technology transfer of assays to QC and external CRO/CMOs.
• Coordinate analysis of in-process and product-related impurities for process comparability studies.
• Conduct scientific research to support drug candidate development and marketed drug research.
• Advise project teams on experiment planning and execution, considering economic, regulatory, and safety factors.
• Present results, interpret data, and draw conclusions from experimental findings.
• Stay current with scientific literature and apply relevant knowledge to projects.
• Represent the company at national and international conferences.

• BS degree with at least 8 years of industry experience OR MS degree with at least 6 years of industry experience.
• Strong knowledge of mass spectrometry, experimental design, and assay development.
• Demonstrated ability to lead in a cross-functional environment and mentor junior team members.
• Ability to work independently with minimal supervision.
• Excellent verbal, technical writing, and interpersonal communication skills.
• Proficient in Microsoft Office applications.

• PhD in Chemistry or related discipline with at least 2 years of industry experience
• Familiarity with techniques such as:
  • Peptide mapping by LC-MS/MS
  • Intact mass analysis
  • MS/MS for protein and carbohydrate structural elucidation/quantification
  • Kinetic analyses
  • Ultra-performance chromatography
  • Proteolytic/chemical processing
• Knowledge of ICH guidelines and GMP.
• Expertise in mass spectrometry analysis software (Protein Metrics, Thermo Bio Pharma Finder, Skyline).
• Experience with data analysis and visualization tools (Python, R, JMP, Spotfire).
• Strong organizational and planning skills.
• Ability to work effectively in a matrixed environment and communicate assay results and issues clearly.

Salary range: $ - $. Base compensation is influenced by experience, qualifications, and location. The role may be eligible for discretionary annual bonus, discretionary stock-based long-term incentives (availability varies by role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance…