Scientist, Analytical Operations

Overview

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working to develop therapies that help improve lives and ensure access across the globe. Our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations.

Our employees are our greatest asset as we work to achieve our bold ambitions. We’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone of the employee experience at Gilead and Kite. As a people leader now or in the future, you are a key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

At Gilead, we set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges and improving the lives of patients for generations to come. As a Scientist, Analytical Operations
, you will perform glycan and glycoprotein analytical work and contribute to structure–function insights across programs.

• Develop and optimize N-glycan analysis workflows (HILIC-FLD, LC-MS, CE-LIF, etc.), including sialic acid, NGNA, and α‑Gal characterization and quantitation.
• Drive advanced structural elucidation of N-glycans using LC‑MS/MS, exoglycosidase sequencing, linkage analysis, monosaccharide analysis, and orthogonal tools.
• Perform intact and subunit mass spectrometry, glycopeptide mapping, and assess glycan occupancy and site-specific heterogeneity and their impact on the protein backbone.
• Integrate glycan structural information with functional outcomes such as Fc receptor binding, Fc silencing/attenuation, CH2 stability, higher-order structure changes, aggregation, and immunogenicity risk.
• Support glycosylation pCQA/CQA assessments with mechanism interpretation and cross-program scientific guidance.
• Support glycan-driven structural differences assessment in comparability studies.
• Author technical reports, glycan characterization summaries, method development documentation, and regulatory submission content.
• Continuously evaluate and implement emerging innovations in glycomics, glycoproteomics, and computational structure–function modeling.

Note:

At a future date, this position will relocate from Oceanside, CA to the Gilead corporate HQ in Foster City, CA.

• BS with +6 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field OR
• MS with +4 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field OR
• PhD with 0 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field.
• Hands-on experience with LC‑MS or MS/MS for glycan or glycoprotein structural characterization.
• Strong analytical reasoning and the ability to interpret complex structure–function relationships.
• Excellent communication skills and ability to work effectively in a cross-functional, matrixed environment.

• Deep expertise in glycan structural elucidation (MS/MS fragmentation, linkage analysis, exoglycosidase workflows).
• Experience linking glycan features to biological activity:
  FcγR binding, effector function modulation, CH2/HOS stability, aggregation, or PK.
• Proficiency with intact/subunit MS, peptide mapping, CE-SDS, SEC-MALS, cIEF and UPLC/HPLC techniques.
• Knowledge of therapeutic antibody glycosylation, Fc engineering strategies, and effector-function silencing frameworks.
• Familiarity with ICH Q5E/Q6B and analytical method qualification for glycan assays.
• Experience with MS analysis tools (Protein Metrics, Peaks, etc.) and analytics platforms (JMP, etc.).

• Create Inclusion — knowing the value…