Scientist, Analytical Operations

Scientist, Analytical Operations

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID‑19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe.

• Develop and optimize N‑glycan analysis workflows (HILIC‑FLD, LC‑MS, CE‑LIF, etc.), including sialic acid, NGNA, and α‑Gal characterization and quantitation analysis.
• Drive advanced structural elucidation of N‑glycans using LC‑MS/MS, exoglycosidase sequencing, linkage analysis, monosaccharide analysis, and orthogonal structural tools.
• Perform intact and subunit mass spectrometry, as well as glycopeptide mapping, to define glycan occupancy, site‑specific heterogeneity, and structural impacts on the protein backbone.
• Integrate glycan structural information with functional outcomes such as Fc receptor binding, Fc silencing/attenuation, CH2 stability, higher‑order structure changes, aggregation, and immunogenicity risk.
• Support glycosylation pCQA/CQA assessments, providing mechanism interpretation, structure‑function justifications, and cross‑program scientific guidance.
• Support glycan‑driven structural differences assessment in comparability studies.
• Author technical reports, glycan characterization summaries, method development documentation, and regulatory submission content.
• Continuously evaluate and implement emerging innovations in glycomics, glycoproteomics, and computational structure‑function modeling.
• At a future date, this position will relocate from Oceanside CA to the Gilead corporate HQ in Foster City, CA.

• BS with +6 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field OR
• MS with +4 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field OR
• PhD with 0 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field.
• Hands‑on experience with LC‑MS or MS/MS for glycan or glycoprotein structural characterization.
• Strong analytical reasoning and the ability to interpret complex structure‑function relationships.
• Excellent communication skills and ability to work effectively in a cross‑functional, matrixed environment.

• Deep expertise in glycan structural elucidation (MS/MS fragmentation, linkage analysis, exoglycosidase workflows).
• Experience linking glycan features to biological activity:
  FcγR binding, effector function modulation, CH2/HOS stability, aggregation, or PK.
• Proficiency with intact/subunit MS, peptide mapping, CE‑SDS, SEC‑MALS, cIEF and UPLC/HPLC techniques.
• Knowledge of therapeutic antibody glycosylation, Fc engineering strategies, and effector‑function silencing frameworks.
• Familiarity with ICH Q5E/Q6B and analytical method qualification for glycan assays.
• Experience with MS analysis tools (Protein Metrics, Peaks, etc.) and analytics platforms (JMP, etc.).

• Create inclusion – knowing the business value of diverse teams and embedding the value of diversity in the way they manage their teams.
• Develop talent – understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential.
• Empower teams – connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account.

Salary range: $ – $. Compensation may also include a discretionary annual bonus, discretionary stock‑based long‑term incentives, paid time off, and a benefits package.

Benefits include company‑sponsored medical, dental, vision, and life insurance plans.

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status and other non‑job related characteristics or other prohibited grounds specified in applicable federal, state and local laws.