Director, Accounting

Mineralys Therapeutics is a clinical‑stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit  Follow Mineralys on Linked In, Twitter and Bluesky.

Mineralys is a fully remote company. The Director of Accounting is a key leadership role within the growing Finance organization, responsible for overseeing the general ledger. This role will lead the build‑out and ongoing optimization of our accounting infrastructure to support commercial product launch, revenue recognition under ASC 606, inventory and cost of goods sold (COGS) accounting, and gross‑to‑net (GTN) processes.

The ideal candidate brings deep public company and commercial‑stage experience in life sciences, strong technical accounting expertise, and a proven track record of leading high‑performing teams in a SOX‑compliant environment. This remote position is based in Colorado, with regular bi‑monthly in‑person meetings with the Finance team in the Boulder region.

• Lead the overall accounting function, including general ledger, accounts payable, payroll accounting, revenue, inventory/COGS, fixed assets, and equity compensation.
• Own the monthly, quarterly, and annual close processes, ensuring accurate and timely preparation of financial statements in accordance with U.S. GAAP and company policies.
• Establish and oversee commercial accounting processes for product revenue, including contract review, revenue recognition under ASC 606, and accounting for variable consideration and gross‑to‑net deductions (e.g., chargebacks, rebates, copay assistance, returns).
• Design and implement inventory and COGS accounting processes to support commercial manufacturing, distribution, and supply chain activities in partnership with Technical Operations and Supply Chain teams.
• Lead the development, documentation, and maintenance of robust accounting policies, procedures, and internal controls, ensuring SOX compliance and scalability as the company grows.
• Support external financial reporting processes in partnership with SEC reporting resources, including support for 10‑Q/10‑K filings, earnings materials, and other regulatory or lender reporting, as applicable.
• Serve as primary point of contact for external auditors on all accounting and internal control matters, managing audit requests and driving issue resolution.
• Evaluate complex and non‑routine transactions (e.g., collaborations, licensing, debt, equity, business combinations, stock‑based compensation) and prepare or review technical accounting analyses and memos.
• Drive continuous improvement and automation across accounting operations, including optimal use of ERP and related systems (e.g., Net Suite, Flo Qast, Tipalti, payroll platforms) to improve efficiency, accuracy, and visibility.
• Build, lead, and develop a high‑performing accounting team, providing coaching, clear objectives, and career development opportunities.

• Deep technical knowledge of U.S. GAAP, including ASC 606 (Revenue from Contracts with Customers), ASC 842 (Leases), and accounting for inventory, equity compensation, and complex arrangements.
• Significant experience in a commercial‑stage biopharmaceutical, biotech, or life sciences company with responsibility for product revenue and gross‑to‑net accounting.
• Proven track record building and leading high‑performing accounting teams in a fast‑paced, high‑growth, public company environment.
• Strong understanding of SOX requirements and experience designing, implementing, and maintaining internal controls over financial reporting.
• Hands‑on, detail‑oriented, and process‑minded with a continuous improvement mindset.
• Excellent analytical, problem‑solving, and decision‑making skills, with the ability to navigate complex and ambiguous issues.
• Effective communicator with the…