Principal, Investments - BrightEdge; Remote

At the American Cancer Society, we're working to end cancer as we know it, for everyone. Our employees and 1.3 million volunteers are raising the bar every single day. We are a culture comprised of diverse backgrounds and experience, to better serve our communities.

The people who work at the American Cancer Society focus their diverse talents on our lifesaving mission. It is a calling. And the people who answer it are fulfilled.

Bright Edge is the innovation, impact investment and venture capital arm of the American Cancer Society. We invest in for-profit, early-stage companies developing cutting-edge, cancer-focused therapeutics, diagnostics, devices, and technologies to fuel and accelerate ACS’s mission of ending cancer as we know it, for everyone.

The Principal will lead sourcing and due diligence for early-stage private company investment opportunities and manage all stages of the investment process, from initial contact through execution. The Principal will interface with internal and external ecosystem partners to identify and evaluate potential investments, conduct in-depth due diligence on both the scientific and business merits of select deals, and develop investment recommendations.

The Principal will also provide guidance and mentorship to Associates and Senior Associates supporting deal execution, and will contribute to evolving Bright Edge’s investment strategy based on insights from curated deal flow and the broader investment landscape. The role requires a high level of self-motivation, sound independent judgment, and a meaningful level of responsibility from the outset.

This position is a remote role, open anywhere throughout the United States. Experience in digital health tech field is preferred.

• Lead the end-to-end investment process for prospective portfolio companies across therapeutics, diagnostics, and healthcare technologies, from sourcing through close, including due diligence, financial modeling, and development of investment recommendations. (25%)
• Lead drafting and delivery of investment memos summarizing the investment thesis, risk profile, and recommendation; present directly to the Bright Edge team and Investment Committee, and participate directly in Investment Committee discussions. (15%)
• Manage and oversee ongoing portfolio company relationships, including board observer responsibilities where applicable, quarterly and annual reporting, and monitoring of company performance, strategy, and market developments. (15%)
• Develop and champion investment views and proactive investment theses based on innovation trends and in-depth understanding of patient‑centric unmet needs; represent Bright Edge at scientific and medical conferences (e.g. AACR, ASCO, etc.) to identify emerging investment opportunities. (10%)
• Provide guidance, mentorship, and quality review to Associates and Senior Associates supporting due diligence, financial modeling, and deal execution; contribute to their professional development. (10%)
• Lead sourcing of investment opportunities and management of co‑investor, venture partner, and ecosystem relationships to drive high-quality deal flow aligned with Bright Edge's investment strategy. (10%)
• Support innovation and venture development initiatives, including review of Bright Edge Innovation program applicants and advising selected participants on scientific and fundraising strategy; engage ecosystem stakeholders across ACS researchers, research institutions, and advisory networks. (10%)
• Contribute to firm‑building initiatives, including investor engagement, fundraising support, and development of external relationships. (5%)

• Minimum Degree
  
  Required:
  
  Bachelor's degree required; advanced degree (PhD, MD, MPH,…