Principal Scientific Advisor; REMOTE

Apply for the Principal Scientific Advisor (REMOTE) role at Charles River Laboratories
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We are seeking an experienced nonclinical drug development professional to serve as a Principal Scientific Advisor within our Discovery and Safety Assessment business units. This position provides opportunity for independent scientific guidance and leadership roles within project teams and functional areas across the organization, with an emphasis on providing innovative advice on nonclinical (pharmacology and toxicology) drug development programs across a broad spectrum of drug modalities.

• Design robust and scientifically sound nonclinical drug development programs in collaboration with clients and internal functional groups.
• Act as the scientific leader for cross‑functional teams for integrated discovery and safety programs.
• Perform gap analyses, support due diligence procedures, and conduct scientific reviews of discovery and/or safety assessment data or reports.
• Provide intellectual input in determining the appropriate discovery and nonclinical safety assessment strategy for complex and novel products, including advanced medicinal products.
• Provide scientific leadership and advice to senior internal stakeholders and external clients.
• Support department leadership regarding strategy and recruitment.
• Work closely with Business Development, Client Services, Account Management, Marketing, and Operations to ensure client needs are understood and addressed.
• Operate from a remote location (US or Europe) and primarily support potential clients in the Eastern Time Zone.

• Master’s degree or PhD in a relevant discipline (e.g., toxicology, pharmacology, biology, immunology).
• Minimum 15 years’ experience in the pharmaceutical/biotech sector or nonclinical contract research, including at least 10 years of nonclinical drug development experience.
• Direct experience in regulated toxicology and drug development.
• Experience in program management and/or Pharm/Tox Program Leadership is desirable.
• Preferable certifications/licensure: DABT, DACVP, or European Registered Toxicologist.
• Applied understanding of regulatory requirements for nonclinical safety assessment studies, including GMP and GLP standards.
• Deep understanding of relevant regulatory guidance documents.
• Demonstrated leadership skills in client, interdepartmental, and business‑development interactions.
• Proficiency in standard software (Microsoft Excel, Word, PowerPoint) and laboratory calculations.

Salary range: $200,000 – $225,000 USD annually. Compensation is influenced by experience, skills, education, certifications, and location.

Charles River is an early‑stage contract research organization that provides discovery and safety assessment services, both GLP and non‑GLP, to support clients from target identification through preclinical development. With over 20,000 employees across 110 facilities in more than 20 countries, we coordinate worldwide resources and apply multidisciplinary perspectives to solve our clients’ unique challenges.

Charles River is an equal‑opportunity employer and is committed to providing equal employment opportunities for all qualified applicants and employees without regard to race, color, sex, religion, national origin, ancestry, age, mental or physical disability, family status, pregnancy, military or veteran status, or any other characteristic protected by federal, state, or local laws.

If you need special assistance or an accommodation due to a disability to complete any part of the application process, contact  This contact is for accommodation requests only and cannot be used to inquire about application status.