Senior Principal Clinical Scientist

Senior Principal Clinical Scientist – Disc Medicine

Apply for the Senior Principal Clinical Scientist position at Disc Medicine.

Disc Medicine is a clinical‑stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients with serious hematologic diseases. Our portfolio focuses on cutting‑edge therapeutic candidates that target fundamental biological pathways of red blood cell biology, such as heme biosynthesis and iron homeostasis. We value collaboration, professional development, scientific integrity, and an inclusive culture that empowers and inspires.

Reporting to the Senior Medical Director, this role supports the DISC‑3405 program focused on hepcidin induction and iron restriction, and may involve additional responsibilities aligned with your interests and experience. You will join an energized cross‑functional team and help drive the clinical program from early to late‑stage studies in a fast‑paced, growing biotech environment.

• Work directly with the Medical Director and the clinical study team in executing early‑stage Phase 1 & 2 studies and pivotal clinical trials.
• Collaborate cross‑functionally with Medical Directors, Pharmacology, Innovation, Pharmacovigilance, external experts, and investigators to accumulate scientific, medical, and safety knowledge necessary to support clinical development plans, study designs, investigator brochures, and protocols.
• Work closely with contract research organizations and the internal Disc team to strategize and meet timelines.
• Monitor and review safety and efficacy data in ongoing studies with the Medical Monitor.
• Represent the clinical study team at sub‑team and program meetings, leading data capture and analysis efforts.
• Develop and maintain relationships with key opinion leaders and principal investigators.
• Participate in investigator meeting planning and execution, including on‑site initiation meetings.
• Lead internal and external team members, vendors, and consultants to develop, review, and evaluate efficacy and safety data for external presentation and regulatory submissions.
• Review content of clinical and regulatory documents, including protocols, INDs, CTAs, investigator brochures, CRFs, annual IND reports, CSRs, and clinical expert reports.
• Organize and present at clinical advisory boards, investigator meetings, DMC and SRC meetings, and medical/scientific meetings.
• Support strategy and business development processes for in‑ or out‑licensing, partnering, and acquisition activities.
• Maintain awareness of internal and external developments—scientific, clinical, competitive, and regulatory—including attendance at major scientific conferences, competitive intelligence activities, and periodic literature review.
• Critically evaluate available information about diseases of interest and the competitive landscape, synthesizing insights to support clinical development and therapeutic area strategy.
• Travel periodically both nationally and internationally.

• PhD, Pharm
  
  D, or MD with research experience.
• 12+ years of related experience in translational or clinical research related to drug development; in‑house biotech or pharma experience preferred.
• Knowledge of clinical research methodology, statistics, data analysis and interpretation, and an ability to think strategically while executing study responsibilities.
• Willingness to take on new responsibilities, expand professional skills, and execute in a high‑paced environment.
• Experience in developing clinical regulatory strategy.
• Ability to identify and build relationships with thought leaders and leading clinical centers.
• Strong academic record demonstrating research productivity is a plus.
• Track record of effective cross‑collaboration within an organization, among teams, and with external groups.
• Clear and effective communication skills, orally and in writing, to internal and external stakeholders.
• Experience interacting with varying levels of internal and external management, academicians, clinicians, and scientists.
• Strong business acumen, including in‑depth knowledge of the multidisciplinary functions involved in drug development (clinical operations, biostatistics, regulatory, commercial operations, etc.), and ability to integrate multiple perspectives into the clinical development process for optimal outcomes.

$209,000 – $283,000 USD

Disc Medicine is an equal‑opportunity employer committed to providing all qualified candidates and employees equal opportunities. We offer comprehensive benefits and competitive compensation packages. The headquarters are in Watertown, MA, and we provide a flexible hybrid work environment that supports remote work as well as on‑site collaboration.

Interested candidates should submit a cover letter and resume to be considered for current and future opportunities.