Senior Site Manager, X-TA

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R&D Operations

Clinical Trial Support

Professional

High Wycombe, Buckinghamshire, United Kingdom

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We are searching for the best talent for a driven Senior Site Manager, United Kingdom to serve as the primary contact point between the Sponsor and the Investigational Site for trials in phases 2-4. In other organisations, the Senior Site Manager may be known as Senior Clinical Research Associate or Monitor. We are hiring for several therapeutic areas (X-TA); preferably the candidate will have experience in Neuroscience, Respiratory, Retinal, Immunology or Oncology.

The head office location is in High Wycombe, Buckinghamshire, UK (relocating to Maidenhead Oct 2026) and this position is home-based with up to 50% travel.

The position is across various therapeutic areas and will include monitoring a variety of trials in different indications. As a Senior Site Manager, you will be responsible for maintaining ongoing inspection readiness and compliance with the clinical trial protocol, Standard Operating Procedures (SOP), Good Clinical Practice (GCP), and applicable regulations from study start‑up through to site closure. Our new colleague should be flexible and is able to work independently.

We are seeking to hire a strong communicator, a quick learner, a problem solver, and a real team player. You will be responsible for oversight of clinical trial protocols at a site level and will collaborate closely with Local Trial Managers (country project manager), Clinical Trial Assistants, and Trial Delivery Managers (regional project manager).

You will be part of a hardworking, enthusiastic, and committed study team eager to deliver and help improve the lives of millions of patients. You will also be part of a wider local UK team that provides mutual support and opportunities to work together to identify new and improved ways of working.

• Activities ranging from site feasibility and selection over site initiation and start‑up, to preparation and conduct of site monitoring, oversight of key performance indicators and site/study close‑out in complex clinical trials.
• The implementation of a site‑level analytical risk‑based monitoring model and for working with the site to ensure timely resolution of issues and deviations identified during monitoring visits.
• Ensuring the accuracy and completeness of all trial data including safety data. Managing timely data entry and query resolution in collaboration with site staff.
• Co‑creating site‑level recruitment and retention strategies and implementation of mitigation actions in partnership with other functional areas.
• Ensuring full documentation of trial related activities in all study files; communicates site and study progress and issues to the Local Trial managers and central study teams.
• Being the local expert in assigned protocols and build the necessary therapeutic area…