Medical Director

GRANITE BIO is a private biotechnology company located in Basel (Switzerland).

GRANITE BIO is supported by top-tier investors with ~$100M raised to date. Based on fundamental research conducted over the last two decades, GRANITE BIO’s is pursuing a differentiated approach to transform inflammatory, autoimmune, and fibrotic conditions. Both our programs are first-in-class monoclonal antibodies for large market opportunities in Immunology and Inflammation. GRT-001, the lead asset, depletes inflammatory monocytes. It has just completed a Phase 1a trial in healthy volunteers and has shown favorable safety and pharmacodynamic effect.

The Phase 1b trial in patients with Ulcerative Colitis has just started. GRT-002 is an IL-3 neutralizing antibody that is thought to play an important role in type II inflammation.

Our company fosters an open, inter-disciplinary, diverse, international and creative working environment. We enable work-from-home options according to our internal workflows. The successful candidate will be highly motivated and enthusiastic with a positive “can do” attitude, attention to details and innovation, strong organizational and communication skills.

• Design, execution/conduct and report of Ph1/2 clinical trials in I&I space
• Contribute to medical team and clinical development strategy
• Provide guidance and expertise in the development of clinical trial protocols and further study relevant documents, such as ICF, IB, SoA, TPP, SAP etc
• Ensure that safety and efficacy data is generated and analyzed according to GCP/SOPs, corporate strategy and timelines
• Perform medical monitoring activities (such as medical oversight of the study, answer questions about eligibility, review safety and adverse event data, medical oversight of coding activities)
• Work closely with cross-functional team members to ensure planning and execution of clinical trials to meet key study milestones
• Play a key role in the development of statistical analysis plan, and in the review, interpretation, and communication of clinical trial data from clinical trials
• Author and develop clinical documents like, clinical study protocols and amendments and review other clinical documents like safety management plan, medical monitoring plan
• Work closely with colleagues from Clinical Operations and Clinical Biomarker department to deliver clinical study program goals and milestones

• Advanced medical degree (MD or equivalent)
• At least 3 years of experience in clinical research or clinical development within the pharmaceutical or biotechnology industry, ideally with exposure to early clinical trials
• Strong ability to build collaborative working relationships with physicians, expert consultants, and external vendors
• Strong analytical mindset with excellent written and verbal communication skills
• Exceptional attention to detail, sound judgement, and strong organisational skills
• Solid knowledge of clinical trial methodology as well as regulatory and compliance requirements for clinical trials
• Good understanding of Good Clinical Practice (GCP), Good Laboratory Practice (GLP), and clinical study design
• Understanding of the framework and complexities of early multi-centre clinical trials, including working with CROs and CDOs
• Ideally, experience in autoimmune disease and/or the IBD / inflammation and immunology (I&I) space
• Effective communicator who shares information transparently and strategically
• Team player with strong listening skills
• Comfortable working in a dynamic, fit-for-purpose biotech environment
• Able to thrive in collaborative and sometimes ambiguous settings, with a proactive and solution-oriented mindset
• Strong planning, organisational, and problem-solving skills, with the ability to support efficient…