Director, Pharmacometrics

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Full Time San Diego, CA, US

2 days ago Requisition

Salary Range: $ To $ Annually

Job Title: Director, Pharmacometrics

Location: San Diego or Remote U.S.

Job Type: Full-Time

Avenzo Therapeutics, Inc. (“
Avenzo
” or “
Company
”) is a clinical-stage biotechnology company focused on developing next-generation oncology therapies for patients. The Company was co-founded in 2022 by Drs. Athena Countouriotis and Mohammad Hirmand (former CEO and CMO of Turning Point Therapeutics, Inc., respectively). Our team is passionate about and committed to advancing a pipeline of potentially differentiated targeted oncology programs that make a difference in the lives of people with cancer.

The Company is headquartered in San Diego, California.

Reporting to the VP, Clinical Pharmacology, the Director, Pharmacometricswill lead the development and execution of pharmacometrics strategies supporting Avenzo’s oncology programs. This role is responsible for applying model-informed drug development approaches, including population PK, PK/PD, and exposure-response modeling, to guide dose optimization, study design, and regulatory decision-making. The Director will collaborate across functions and with external partners to generate quantitative insights that enable efficient clinical development and support regulatory submissions and interactions.

• Provide strategic leadership and subject matter expertise in pharmacometrics and clinical pharmacology across our development portfolio
• Develop and execute model-informed drug development strategies, including population PK, PK/PD, exposure-response, and simulation analyses to support program decision-making
• Lead pharmacometric activities and contribute clinical pharmacology expertise as a core member of cross-functional program teams, partnering closely with Clinical Development, Biometrics, Regulatory Affairs, and other internal and external subject matter experts
• Develop and apply pharmacometric analyses to support dosing recommendations for special populations, dose modifications, drug–drug interactions, organ impairment, and other intrinsic and extrinsic factors
• Resolve complex scientific and technical challenges with cross-program impact, contributing to dose justification, benefit-risk assessments, and regulatory development strategies
• Analyze and interpret clinical and translational PK/PD data and oversee pharmacometric modeling activities to inform development and regulatory decisions
• Develop clinical pharmacology plans and dosing strategies from first-in-human studies through late-stage clinical development
• Author and review clinical pharmacology content for protocols, clinical study reports, regulatory submissions, briefing documents, and health authority interactions
• Represent Clinical Pharmacology and Pharmacometrics in regulatory agency meetings and responses, supporting global development and registration strategies
• Provide oversight of pharmacometric platforms, modeling environments, reporting workflows, and external vendors to ensure high-quality and efficient execution
• Manage pharmacometrics activities, budgets, timelines, and deliverables to ensure successful program execution
• Influence development strategy through quantitative analyses and scientific recommendations that support portfolio-wide objectives

• PhD degree in pharmacometrics, biological/pharmaceutical sciences, bioengineering, biostatistics, engineering, data science, or a related disciplines with 8+ years of progressive pharmacometrics…