Clinical Variant Scientist

• Salary Range : $79,601.60 USD to $ USD

Showing 1 location

Remote
United States

Schedule :
Monday - Friday (40 hrs/wk)
8:00 AM - 5:00 PM

Department
:
Genomics Analysis - 396

*** Exact compensation will vary based on skills and experience.***

Primary Purpose :

The Clinical Variant Scientist is responsible for the interpretation and classification of genetic variants identified through clinical testing, ensuring accurate and clinically relevant reporting. This role involves reviewing genomic data, applying established guidelines (e.g. ACMG, AMP, Clin Gen), and integrating evidence from scientific literature, databases, and internal resources. The scientist collaborates with laboratory teams, genetic counselors, and medical directors to provide high-quality variant assessments and reports that support patient care.

Additional responsibilities include maintaining up-to-date knowledge of genomic research and guidelines, contributing to quality assurance processes, and assisting in the development of standard operating procedures and best practices for variant interpretation. This position requires that roughly 85-95% of time is spent on analysis of clinical cases, with the remainder of time spent on other duties. This position demands focused individuals with attention to detail and strong critical thinking skills.

This is a fully remote position and will be focused on analysis of Oncology NGS tests and somatic variant interpretation.

About ARUP :

ARUP Laboratories is a national clinical and anatomic pathology reference laboratory and an enterprise of the University of Utah and its Department of Pathology. Based in Salt Lake City, Utah.

ARUP proudly hires top talent to create a work environment of diversity, professional growth and continuous development. Our workforce is committed to the important service we provide to over one million patients each month. We always strive for excellence and have a strong desire to have involvement with the advances in medicine and the role laboratory services plays within each patient’s life.

We never forget that there is a patient behind every specimen we receive.

We are looking for individuals who want to contribute to ARUP's culture of accountability, integrity, service, and excellence. Consider joining our dynamic team.

Essential Functions :

Perform either somatic or germline variant interpretation using standard nomenclature and professional standard classification guidelines (e.g. ACMG, AMP, Clin Gen).

Evaluate quality of data produced from clinical laboratory testing, primarily from next generation sequencing/massively parallel sequencing (NGS/MPS) platforms.

Research and determine clinical significance of variants based on medical literature, external databases, and computational prediction software.

Understand basic concepts in protein structure and function, RNA splicing, and gene regulation, and how these relate to genetic mechanisms of disease and sequence variants observed in a given specimen.

Understand experimental methods, data analysis methods, and inferences that can be applied to both single-gene experimentation and high-throughput analyses.

Collect and integrate data from multiple sources within the context of cancer biology and/or heritable disorders, and the potential impact on clinical care.

Perform data entry with high accuracy and be able to recognize inconsistencies and initiate resolution.

Assess the plausibility of laboratory results through correlation of data with patient demographics and clinical symptoms.

Draft clinical reports with accuracy and consistency for review by medical directors.

Work effectively with other scientists, staff, directors, and management to troubleshoot unique scenarios, identify areas to optimize and…