Principal Project Manager; office locations

Position: Principal Project Manager (we have office locations  amp )
Company Description

Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare. Building on the 100,000 Genomes Project, we support the NHS’s world-first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives. By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future.

Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK’s position as the best place to discover, prove and benefit from genomic innovations.

We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.

Behind the Healthcare and Research outcomes, Genomics England delivers through designing, developing and operating complex healthcare software systems.

We're on the cusp of big changes with the real prospect of genomics becoming the fabric of everyday healthcare through the lifetime – from birth to old age.

Job Description

We are looking for a Principal Project Manager to join the Office of the Chief Technology & Product Officer (CTPO). This is an exciting opportunity to shape and deliver high-impact technology and product initiatives that support our wider mission.

You will bring clarity, structure, and momentum to complex projects, helping teams work together effectively and ensuring strong governance across a diverse portfolio.

Alongside leading a major ITSM/CMDB transformation programme (70%), you will help bring consistency, visibility, and direction across the wider CTPO portfolio (30%), supporting delivery that is thoughtful, well-governed, and impactful.

Everyday responsibilities include:

Mange complex projects end to end, ensuring successful delivery, by managing planning, reporting, and end-to-end risk and issue management with a structured, and consistent approach.  
Build strong, trusted relationships with senior leaders, Service Management, Product, Service Design, and suppliers to enable effective collaboration and shared outcomes.  
Provide oversight across the CTPO portfolio, strengthening governance, improving visibility, and supporting informed decision-making.  
Coordinate programme and governance boards, ensuring reporting, escalation, and updates are clear, timely, and transparent for all stakeholders.  Skills and experience for success:

Experience leading complex projects in large, matrixed environments.
A collaborative approach and the ability to build trusted relationships with senior stakeholders and executive leaders.
A strong track record of delivering end-to-end programmes that create meaningful and lasting impact.
Confidence in setting up and managing project governance, and risk management across complex delivery environments.
The ability to bring structure, clarity, and calm to fast-moving and evolving portfolios.
Strong communication skills, with the ability to turn complexity into clear and useful insight for a range of audiences.

Qualifications

Whilst Project Management certifications are desirable, we are mostly interested in your experience.

Additional Information

Salary from: £70,000

Closing date for applications - Friday 19th June

Being an integral part of such a meaningful mission is extremely rewarding in itself, but in order to support our people, we’re continually improving our benefits package. We pride ourselves on investing in our people and supporting them to achieve their career goals, as well as offering a benefits package including:

Generous Leave: 30 days’ holiday plus bank holidays, additional leave for long service, and the option to apply for up to 30 days of remote working abroad annually (approval required).
Family-Friendly:
Blended working arrangements, flexible working, enhanced…