District Manager - Austin, TX

If you are a job seeker with a disability and require a reasonable accommodation to apply for one of our jobs, you will find the contact information to request the appropriate accommodation by visiting the following our Accessibility Accomodation for Applicants page.

• Posted on November 12, 2026

Showing 1 location

Remote
United States

• Commercial - Ionis
• Full-Time
• Requisition #: IONIS
  004161

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

DISTRICT MANAGER - AUSTIN, TX

POSITION SUMMARY:

The District Manager is a field-based commercial leader responsible for building and leading a high-performing team of Clinical Account Specialists supporting the launch and ongoing growth of Ionis' first wholly owned commercial product as its indication expands beyond Familial Chylomicronemia Syndrome to severe hypertriglyceridemia. The role reports to the Regional Executive Director.

The District Manager owns district performance and is accountable for the team consistently meeting or exceeding sales goals. This leader translates regional and brand strategy into clear territory expectations, measurable activity and performance standards, disciplined execution and timely action when results or leading indicators are off plan. Success requires a manager who can build a high-accountability culture, coach in the field, use data to direct effort, develop and differentiate talent, and maintain momentum across a large and evolving customer universe.

The District Manager will ensure each CAS proactively develops their territory, expands and activates the customer base, creates appropriate urgency with healthcare professionals and converts education into measurable customer action. The manager will partner closely with cross-functional colleagues to improve the HCP and patient experience while retaining clear ownership for district execution and results. All activities must be conducted with integrity and in accordance with the Ionis Code of Ethics and Business Conduct and all applicable policies.

KEY RESPONSIBILITIES:

District strategy and business ownership

• Own the district business plan and the achievement of quarterly…