Senior Scientist

Amgen’s mission is to serve patients living with serious illnesses. Since 1980, the company has pioneered biotechnology and impacts millions of patients worldwide through oncology, inflammation, general medicine, and rare disease programs. Amgen’s culture is collaborative, innovative, and science‑based, and the organization values challenges that drive scientific progress and patient impact.

The Department of Inflammation Research seeks a dedicated, driven, and independent Principal Scientist (manager) to join the In Vivo Pharmacology (IVP) group. The role involves designing and executing experiments that explore and understand the pharmacology of drug targets; generating, communicating pharmacology and preclinical data to support research projects; and providing technical expertise to therapeutic area scientists. The candidate may manage up to one report, contribute to project teams, and collaborate with scientists at multiple Amgen sites.

• Independent and proactive scientist who contributes to cutting‑edge science and serves patients in a highly productive team environment.
• Strong understanding of Immunology and Inflammation biology and principles.
• Willingness and curiosity to learn and explore new research areas.
• Hands‑on expertise in animal (mouse and rat) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy).
• Experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models, including colitis, lupus, and arthritis models.
• Experience with cellular, biochemical, histological, and molecular biology assay techniques (e.g., ELISA, MSD, quantitative RT‑PCR, BCA protein measurements) and multicolor flow cytometry including spectral flow.
• Computer literacy, with proficiency in Graph Pad Prism, Excel, PowerPoint, and Word.
• Exceptional attention to detail, organizational and communication skills, and accurate & timely record keeping and data analysis.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Ability to work in a flexible, team‑oriented environment.

• Doctorate degree, or
• Master’s degree and 2 years of drug discovery experience, or
• Bachelor’s degree and 4 years of drug discovery experience.

• PhD degree and post‑doctoral training (or drug discovery experience) in Immunology, inflammation, autoimmune disease, or related disciplines; 3–5 years of management experience.
• Experience leading in vivo contributions on project teams.

• Comprehensive benefits package including retirement and savings plans with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program.
• Stock‑based long‑term incentives.
• Award‑winning time‑off plans and bi‑annual company‑wide shutdowns.
• Flexible work models, including remote work arrangements where possible.

Amgen is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. Individuals with disabilities will receive reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to enjoy other employment benefits and privileges.

Please contact Amgen to request accommodation.