Sr. Leader Discovery Toxicology

Location: St. Louis
Sr. Leader Discovery Toxicology page is loaded## Sr. Leader Discovery Toxicology remote type:
Remote locations:
St. Louis, MOtime type:
Full time posted on:
Posted Todayjob requisition :
JR100983

The Senior Director, Discovery Toxicology is responsible for providing scientific and strategic leadership to the Integrative Toxicology function within the Discovery & Translational Sciences (DTS) division. This role oversees the direction and execution of Investigative Toxicology efforts, with a focus on evaluating and mitigating safety risks associated with early-stage therapeutic targets. The position requires a strong foundation in discovery and preclinical toxicology, with the ability to interpret complex data across in vitro, in vivo, and human tissue-based models.

The role plays a key part in enhancing the translational relevance of toxicological assessments and supports cross-functional collaboration to advance internal and client drug development programs.
This is a remote role.
** Key Accountabilities
*** Design and implement modern toxicology strategies to support all stages of discovery as well as new indications investigations during clients’ phased clinical studies and/or post-marketed therapeutics.
* Drive the integration of toxicology as practiced at Inotiv’s multiple sites into a single, coordinated network that operates with shared goals, stage-appropriate standards, and best practices.
* Lead mechanistic investigations using in vitro, in vivo, and ex vivo approaches.
* Contribute to the scientific advancement and programmatic inclusion of Novel Alternative Methods (NAM) in the Pharmacologic and Toxicologic assessment of therapeutics
* Evaluate species relevance to improve translatability of nonclinical findings to human risk.
* Collaborate cross-functionally with pharmacology, DMPK, pathology, bioinformatics, and clinical teams to integrate data and guide compound development.
* Contribute to the discovery and application of translational safety biomarkers to support preclinical-to-clinical transitions.
* Anticipate and mitigate safety liabilities early in the discovery process, including off-target effects and distinguishing adaptive from adverse responses.
* Mentor and develop a high-performing team of toxicology investigators and laboratory scientists.
* Represent Discovery Toxicology in internal project teams, governance forums, and external regulatory interactions, as needed.
* Monitor scientific and regulatory advancements to continuously innovate and evolve toxicology strategies.
* Lead a multidisciplinary team including Study Directors, Investigators, and Technical Scientists.
* Complete assigned all assigned training.
* All other duties as assigned.
* Other special projects and duties as assigned
** Minimum Requirements
*** PhD in Toxicology, Pharmacology, or a related biomedical science, with 15+ years of experience in discovery or investigative toxicology within the pharmaceutical, biotech, or CRO industry.
* Additional qualifications such as DVM or Board Certification in Pathology are strongly preferred.
* Proven expertise in designing and interpreting in vitro, in vivo, and ex vivo toxicology studies to investigate mechanisms of toxicity.
* Track record of successfully supporting drug discovery programs from hit identification through candidate nomination.
* Deep understanding of molecular and cellular toxicology, interspecies differences, drug metabolism, and mechanisms of human relevance.
* Experience in biomarker discovery and translational safety assessments is highly desirable.
* Strategic thinker with the ability to synthesize complex scientific data into actionable development plans.
* Strong leadership skills with experience managing and developing scientific teams.
* Excellent communication and cross-functional collaboration skills.
* ** Proficiency with Microsoft Office Suite** (Word, Excel, PowerPoint, Outlook) is required.
** Critical Success Factors**
* ** Results Driven.
** Internal drive toward action to efficiently, timely, and accurately achieve results. Sets high but achievable standards for self and others. Seeks opportunities to improve process and outcomes. Constantly reviews…