Senior Research Scientist, Cell Engagers

Job Description

Takeda Development Center Americas, Inc. is seeking a Senior Research Scientist, Cell Engagers to contribute to discovery projects by independently designing and developing well-defined mechanistic experiments in vitro and ex vivo to identify mechanisms of action (MoA) for oncology cell engager research. The role involves leading from the lab to advance novel and differentiated products in collaboration with cell therapy oncology to incorporate new Vδ1 isolation strategies, proposing novel projects based on internal results, external partners, and published reports, and communicating study plans, results, and value to internal and external audiences.

• Design and develop well-defined mechanistic experiments in vitro and ex vivo for oncology cell engager research.
• Lead from the lab to advance novel and differentiated products in collaboration with cell therapy oncology toward clinical milestones.
• Propose novel projects based on internal results, external partners, and published reports.
• Actively participate with the team to isolate and phenotype Vδ1 cells from blood and skin and collaborate with the Cell Therapy team to incorporate new Vδ1 isolation strategies for cell engager programs in vitro.
• Use immune cell characterization and function assessment such as multi‑color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assay, and other molecular‑based assays to perform analysis, interpret results, and determine appropriate action.
• Prepare and present comprehensive technical or project reports and formal presentations and posters to full range of internal/external audiences and contribute to IND report and other regulatory filings.
• Maintain laboratory notebooks and keep in compliance with Takeda policies.
• Independently design cytokine fusion strategy to enhance Vδ1 biology for solid tumors and help with external collaborations/CROs and establish new protocols.

• Master’s degree in Cancer Immunology and Immunotherapy, Cancer Sciences, or related field plus 5 years of related experience.
• Prior experience must include isolation of gamma‑delta T cells from blood and tissue, research gamma‑delta T cell culture and expansion methodology to improve yield and cytotoxicity, and development of functional and characterization experiments via flow cytometry, spectrometry, and chemiluminescence of isolated Vδ1 cells.
• Experience with gene engineering of Vδ1 cells and evaluation of novel immunotherapy products based on Vδ1 gamma‑delta cell biology.

Full time. $137,000 – $234,800 per year. Up to 20% remote work allowed.

Qualified applicants can apply at  Please reference job #R0168852. EOE