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Principal Scientist​/Associate Scientific Director - Computational Chemistry

Remote / Online - Candidates ideally in
England, UK
Listing for: Hyper Recruitment Solutions
Remote/Work from Home position
Listed on 2026-07-18
Job specializations:
  • Research/Development
    Pharmaceutical Science/ Research, Drug Discovery, Research Scientist, Medicinal Chemist
  • Pharmaceutical
    Pharmaceutical Science/ Research, Drug Discovery, Medicinal Chemist
Salary/Wage Range or Industry Benchmark: 90000 - 140000 GBP Yearly GBP 90000.00 140000.00 YEAR
Job Description & How to Apply Below
Position: Principal Scientist / Associate Scientific Director - Computational Chemistry

Principal Scientist / Associate Scientific Director - Computational Chemistry

A leading company in the industry is seeking a Principal Scientist / Associate Scientific Director – Computational Chemistry to join their team based in the Chapel-en-le-Frith area, with a hybrid working model. Remote working from home can also be considered.

As the Principal Scientist / Associate Scientific Director, you will be instrumental in solving complex drug discovery challenges and guiding medicinal chemistry programmes.

Key Duties and Responsibilities

Your duties as the Principal Scientist / Associate Scientific Director will be varied; however, the key duties and responsibilities are as follows:

  • Deliver high‑quality computational chemistry support across drug discovery programmes, from target identification through to clinical candidate nomination.
  • Apply structure‑based and ligand‑based small molecule drug design methods, including docking, QSAR, pharmacophore modelling, virtual screening, MD, and QM calculations, to guide medicinal chemistry and solve complex design challenges.
  • Provide expert guidance to medicinal chemists and multidisciplinary project teams, integrating computational insight with experimental data.
  • Mentor and develop computational chemists, setting high standards for scientific thinking, quality, and integrity.
  • Role Requirements

    To be successful in your application to this exciting role as the Principal Scientist / Associate Scientific Director we are looking to identify the following on your profile and past history:

  • Relevant degree in computational chemistry or a closely related discipline.
  • Proven industry experience in drug discovery within pharma, biotech, or CRO settings, managing client projects.
  • A working knowledge and practical experience with structure‑based and ligand‑based small molecule drug design and the practical application of computational tools.
  • Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer.

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    Position Requirements
    10+ Years work experience
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