Associate Director, Portfolio Project Management

Full-time

Bicycle Therapeutics is a clinical‑stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle® molecules attractive candidates for drug development.

The company is evaluating nuzafatide pevedotin (formerly BT5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; a pipeline of Bicycle® Radio conjugates (BRCs) and imaging agents; zelenectide pevedotin (formerly BT8009), a BDC® targeting Nectin‑4, a well‑validated tumor antigen; and, through various partnerships, the use of Bicycle®technology to develop therapies to treat diseases in a range of therapeutic areas.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous
  . We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission
  . You can’t change the world if you don’t have determination.
• We are One Team
  . We only succeed when we work together.

At Bicycle, we benefit from a hybrid style working arrangement, allowing employees where possible the opportunity to collaborate and engage with their coworkers in person while also benefiting from the flexibility of remote working. A typical hybrid arrangement for this role is 3 days onsite per week at our Cambridge, UK office, with the remainder of your working week remote.

Your mission is to serve as the operational engine of our cross‑functional pipeline, seamlessly bridging Research & Innovation (R&I) and Clinical Development. Working under the guidance of the VP, Portfolio Strategy & Scientific Affairs and our Director‑level project management leadership, you will oversee the day‑to‑day coordination, tracking, and operational management of our therapeutic portfolio. By maintaining highly accurate integrated Gantt charts, orchestrating clear meeting agendas, capturing precise action‑oriented minutes, and tracking project interdependencies across departments, you will enable our scientific and clinical teams to execute seamlessly, mitigate risks, and deliver the next wave of novel Bicycle® therapeutics on time and within budget.

• Master Timeline & Gantt Chart Management: Create, maintain, and continuously optimize integrated master project plans and detailed Gantt charts across both Research & Innovation (R&I) and Clinical programs, identifying critical paths and key interdependencies.
• Meeting Administration & Governance Support: Coordinate and administer project team meetings. This includes driving the preparation of collaborative, objective‑focused agendas, capturing high‑quality, action‑oriented minutes, and systematically tracking follow‑up deliverables to closure.
• Portfolio Dashboards & Reporting: Maintain portfolio‑level tracking tools, dashboards, and risk registries under the guidance of Director leadership to provide senior stakeholders with high‑visibility, real‑time access to program statuses.
• Documentation & Repository Stewardship: Ensure all project‑related documentation, decision logs, and collaboration portals (e.g., SharePoint, MS Teams) are meticulously organized, up‑to‑date, and standardized across R&I and Clinical teams.
• Publications Support: Support publications tracking, timelines and maintaining a publications repository across R&I and Clinical.

Pipeline Delivery & Operational Execution

• Cross‑Functional Execution: Collaborate with team members across nonclinical, translational, clinical, regulatory, and CMC functions to ensure that project objectives and milestones leading to IND/CTA filings and clinical trial milestones are executed within scope and budget.
• Resource & Timeline…