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Senior Clinical Trial Manager Job Description

Senior Clinical Trial Manager

At ICON Strategic Solutions, you will work in a sponsor-dedicated model, supported by ICON's global expertise.

As the world's largest FSP organisation, with over 90 sponsor partnerships, we offer stability, career development and a collaborative environment where your work contributes to the development of treatments that benefit patients worldwide.

As a Senior Clinical Trial Manager at ICON, you will be responsible for leading country-level clinical study delivery, ensuring studies are executed in accordance with protocol requirements, ICH GCP, applicable regulatory requirements, budget, timelines, and quality expectations. You will provide leadership to local study teams while driving study execution from start‑up through close‑out and inspection readiness.

In this role, you will be responsible for the oversight and delivery of clinical studies at the country level, ensuring operational excellence across the study lifecycle.

• Lead and coordinate Local Study Teams, including CRAs and study support personnel, to deliver clinical studies according to agreed timelines, budget, and quality standards.
• Oversee country‑level study start‑up activities, including feasibility assessments, site selection, site qualification, regulatory and ethics submissions, and site activation.
• Manage study progress at country level, proactively identifying risks, implementing mitigation strategies, and ensuring timely resolution of operational issues.
• Oversee site monitoring activities and provide guidance to CRAs to ensure compliance with study protocols, ICH GCP, sponsor requirements, and local regulations.
• Ensure appropriate management of study budgets, investigator contracts, site payments, study systems, and vendor activities within the country.
• Maintain inspection readiness through effective oversight of TMF/eTMF documentation, quality management activities, audits, and regulatory inspections.
• Collaborate with global study teams, investigators, vendors, and cross‑functional stakeholders to support patient recruitment and successful study delivery.

To succeed in this role, you will bring strong clinical operations leadership experience, excellent project management skills, and the ability to lead cross‑functional teams in a matrix environment.

• Bachelor's degree in Life Sciences, Nursing, Pharmacy, or a related scientific discipline
• Significant clinical research experience in a Clinical Research Associate (CRA), Senior CRA, Study Management, or related Clinical Operations role.
• Strong knowledge of ICH GCP, clinical trial regulations, and country‑specific regulatory requirements.
• Proven experience leading cross‑functional teams and managing clinical studies across the full study lifecycle.
• Strong project management, stakeholder management, and risk mitigation skills with the ability to manage multiple priorities effectively.
• Willingness to travel as required (approximately 25%)
• 3 – 5 years of experience in project management, with experience in cardiovascular and respiratory therapeutic areas being desirable

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Our success depends on the quality of our people. That's why we've made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well‑being and work‑life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your…