Research Laboratory Tech Sr; term-limited

Position: Research Laboratory Tech Sr (term-limited)
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Mission Statement Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Job Summary The Division of Rheumatology is seeking a highly motivated, full-time Research Lab Technician Senior to support translational research focused on cancer immunology and the development of novel immunotherapies for prostate cancer. The successful candidate will work in a collaborative research environment and contribute to molecular, cellular, and animal studies examining immune-cell migration, activation, and anti-tumor activity.

Responsibilities
* Maintain and culture primary human immune cells and established cancer cell lines. Perform cell-based assays to evaluate immune-cell migration, activation, and tumor-cell killing. Prepare samples and perform ELISA and other plate-based assays. Conduct multicolor flow cytometry and assist with data analysis. Perform RNA isolation, cDNA synthesis, quantitative real-time PCR, and western blotting. Assist with CRISPR-based gene-editing experiments and validation of gene knockout or knockdown cell lines.

Assist with rodent handling and in vivo prostate cancer studies, including treatment administration, tumor monitoring, and tissue collection. Process cells and tissues for flow cytometry, histology, immunohistochemistry, and immunofluorescence. Acquire and analyze microscopy images using fluorescence microscopy. Maintain accurate laboratory records and assist with data collection, organization, analysis, and interpretation. Collaborate with laboratory members and institutional core facilities on research projects.

Contribute to laboratory organization, reagent preparation, equipment maintenance, and general laboratory operations.

Required Qualifications
* Bachelors degree in Biology, Biomedical Sciences, Immunology, or a related scientific field, and 1-2 years experience. An equivalent combination of education and experience may be accepted, including relevant undergraduate and graduate student work experience.  Hands-on laboratory experience with mammalian cell culture and standard molecular or cellular biology techniques.

Experience with one or more of the following: rodent handling, flow cytometry, ELISA, histology, immunohistochemistry, fluorescence microscopy, qRT-PCR, or western blotting. Proficiency with standard data-analysis and office software, such as Graph Pad Prism, ImageJ, and Microsoft Office. Strong organizational, written, and verbal communication skills. Ability to maintain accurate records, follow established protocols, and manage multiple experimental tasks. Ability to work independently while contributing effectively to a collaborative research team.

Willingness to work with human-derived specimens, cultured cancer cells, and laboratory animals in accordance with applicable safety and research protocols.

Why Join Michigan Medicine?

Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems.

In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.

What Benefits can you Look Forward to?

Excellent medical, dental and vision coverage effective on your very first day2:1 Match on retirement savings

Modes of Work Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any…