Postdoc 'Overcoming resistance mechanisms in pancreatic cancer solid cancers

We are seeking a highly motivated and talented Postdoctoral Researcher to lead a cutting-edge research line focused on overcoming resistance mechanisms in pancreatic cancer and other solid cancers. Using multidisciplinary fields such as peptide-based targeting, and nanomedicine platforms, you will design and evaluate novel therapeutic strategies aimed at reprogramming the tumor microenvironment to potentiate chemo- and immunotherapy in vitro and in vivo.

• Nanomedicine & Targeted Delivery:
  Design, evaluate, and characterize peptide-functionalized and nanoparticle-based drug delivery systems tailored for targeted stromal modulation and enhanced therapeutic delivery.
• Preclinical Evaluation:
  Conduct rigorous in vitro and in vivo efficacy, bio-distribution, and mechanistic studies using PDAC disease models.
• Data Integration & Dissemination:
  Analyze multi-layered experimental data, prepare high-impact scientific manuscripts, and present findings at major international conferences.
• Project Leadership & Mentorship:
  Actively contribute to project management within the ERC framework, collaborate across multidisciplinary networks (biologists, clinicians, materials scientists, and pharmaceutical researchers), and mentor PhD candidates and junior researchers.

Profile

• Education:
  
  A completed PhD in Cancer Biology, Drug Delivery, Nanomedicine, Molecular Medicine, or a closely related discipline.
• Domain Expertise:
  Demonstrated experience in cancer cell biology, tumoral stroma dynamics, or microenvironment targeted therapy.
• Methodological
  
  Skills:
• Proven hands-on expertise in nanomedicine formulation/characterization or targeted delivery systems.
• Solid grounding in standard molecular biology, flow cytometry, confocal microscopy, and histological/spatial analysis techniques.
• 3D tissue modeling (e.g., organoids, microfluidics/organ-on-chip, complex co-cultures, or 3D bioprinting).
• Experience with relevant preclinical in vivo oncology models (preferred).
• Track Record: A strong publication record in top-tier peer-reviewed scientific journals relative to your career stage.
• Soft Skills:
  
  Outstanding problem-solving skills, excellent command of written and spoken English, and a collaborative mindset suited for a fast-paced scientific environment.

• Fixed-term contract: 2 years.
• Well arranged With us, you receive 8% holiday allowance, an 8.3% end-of-year bonus, and - depending on your role - an irregular hours allowance ranging from 47% to 72%. In addition, you are entitled to 176 vacation hours per year (based on a 36-hour work week).

• You will receive a €0.18 per kilometer travel allowance. Public transport costs (2nd class) are fully reimbursed. If you work partly or entirely from home, you will receive €2.40 per home-working day. This way, everything is well arranged—wherever you work.
• Flexible benefits scheme With our flexible benefits scheme, you decide how to use part of your employment benefits. Purchase extra leave days or use your year-end bonus to buy a bicycle with tax benefits. You choose what suits you best.

We believe a good start is important. Thanks to our onboarding app, you’ll be well prepared even before your first working day. During the introduction day, you’ll get to know your colleagues and our organization.

If you are required to wear Radboudumc work clothing and change outside working hours, you will receive a changing allowance of €80 gross per month for a full-time position, provided this applies to your role.

At our organization, your work is valued. Your salary will increase in line with the collective labor agreement in two steps: by 3.5% as of July 1, 2026, and an additional 3.5% as of May 1,…