Scientist, mRNA Formulation

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Our approach to R&D Scientist, mRNA Formulation Join GSK as a Scientist focused on mRNA formulation, where you will design and develop innovative mRNA delivery systems that support our vaccine and medicine discovery programs. Working closely with colleagues across disciplines, you will lead laboratory studies that enhance product understanding and accelerate development. We value curious, motivated scientists who take ownership, communicate clearly, and thrive in a collaborative environment.

This role offers you a chance to grow your skills, make a meaningful impact, and contribute to GSK’s mission of uniting science, technology, and talent to get ahead of disease together.

This role is located Cambridge, MA in the United States and requires working on-site. Hybrid or remote work options are not available for this position.

• Design, prepare, and evaluate mRNA formulations and delivery systems, including lipid nanoparticle (LNP) platforms, to assess stability, compatibility, encapsulation efficiency, and performance.
• Develop and execute formulation studies, stability studies, and stress studies to advance mRNA vaccine and therapeutic programs.
• Characterize physicochemical properties of mRNA formulations using analytical techniques such as dynamic light scattering (DLS), zeta potential, chromatography, and thermal analysis.
• Analyze and interpret experimental data, identify formulation risks and opportunities, and recommend strategies to improve product quality, stability, and performance.
• Collaborate closely with analytical, process development, regulatory, and quality teams to support project goals and advance development programs.
• Maintain accurate laboratory records, prepare study reports, and communicate scientific findings through presentations and technical documentation.
• Maintain the drug product laboratory space in a safe, organized, and inspection‑ready manner.
• Support troubleshooting and problem‑solving efforts to address formulation challenges.

• BS, MS, or PhD in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, Chemistry, Biochemistry, Biomedical Engineering, or a related scientific discipline (BS and a minimum of 5 years of relevant experience, MS and a minimum of 3 years of relevant experience, or PhD and 0 years of relevant experience).
• A minimum of 1 year of hands‑on laboratory experience developing and evaluating mRNA‑LNP formulations or other nucleic acid delivery systems.

• Advanced degree (Master’s or PhD) in a relevant discipline.
• Experience with vaccine formulation, protein biologics, nanoparticle delivery systems, or other advanced drug delivery technologies.
• Experience designing and executing formulation studies, stability studies, and other drug product development experiments.
• Practical knowledge of lipid nanoparticle formulation development and characterization.
• Knowledge of high‑throughput formulation screening and stability study design.
• Familiarity with process development, scale‑up considerations and manufacturing handoffs.
• Familiarity with characterization techniques used to evaluate formulation quality, such as…