Principal Scientist, Oncology Drug Discovery

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The Intracellular Targeted Cancer Therapeutics (ITCT) Biology Unit within the Oncology Research Unit is seeking an experienced Cancer Biologist for an Investigator role that will support a growing portfolio of precision oncology assets. The successful candidate will have a background in cancer biology with experience designing and executing biological studies to understand the mechanism of action small molecule cancer therapeutics. We value curious, motivated scientists who take ownership, communicate clearly, and thrive in a collaborative environment.

This role offers you a chance to grow your skills, make a meaningful impact, and contribute to GSK’s mission of uniting science, technology, and talent to get ahead of disease together. This role can be in the United States in either Cambridge, MA or Upper Providence, PA and requires working on-site. Hybrid or remote work options are not available for this position.

This role will provide YOU the opportunity to lead key activities to progress YOUR career.

• Work within a dynamic and global matrix team environment providing basic and translational biology support for target validation, drug discovery, and early clinical development of novel small molecule cancer therapies.
• Work independently to design, execute, and/or oversee impactful in vitro experiments to inform the development of portfolio assets.
• Champion innovative experimental techniques or technologies, including medium-throughput scalable assay development, target-specific mechanistic biology, and monotherapy and combination anti-cancer efficacy testing of assets.
• Build communication networks across the Oncology Research Unit and broader organization.
• Guide the maturation and de-risking of novel therapeutic concepts.

• BS, MS, or PhD in Cell, Molecular, or Cancer Biology, Pharmacology, or a related life sciences field (BS and a minimum of 5 years of relevant industry experience, MS and a minimum of 3 years of relevant industry experience, or PhD and 0 years of relevant industry experience).
• A minimum of 3 years of experience in designing, executing, and analyzing cellular and molecular biology experiments using small molecular therapeutics and a diverse array of current scientific techniques.

• A minimum of 2 years of drug discovery experience in a biotech, preclinical CRO or pharmaceutical company.
• Deep knowledge in the field of molecular oncogenesis, signaling pathway, bivalent or molecular glue modality.
• Deep expertise in assay development in a drug discovery setting.
• Experience in applying genomic editing techniques to dissect target biology and drug mechanisms.
• Proven track record of scientific expertise and achievement in cell biology and cancer biology through peer-reviewed publications.
• Working knowledge of omic methods (e.g., sequencing, transcriptomics, and/or proteomics) and databases (e.g., TCGA, CCLE, Dep Map, etc.).
• Attention to detail and proficient reasoning skills in experimental design, data analysis, statistical methods, and interpretation.
• Independence, problem-solving abilities, self-motivation, resourcefulness, and organizational, interpersonal, and communication skills and the ability to work efficiently in a fast-paced team environment.

If you are based in Cambridge, MA;
Waltham, MA;
Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $115,500 to $192,500. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role.

• health care and other insurance…