Postdoctoral Appointee - Bioimaging Microscope, Onsite

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We seek one postdoctoral appointee to work in the area of nonlinear optical bioimaging microscopy, primarily working with PI Christopher Kliewer. Our team is building a new bioimaging microscope with fluorescence lifetime imaging and time-resolved coherent anti-Stokes Raman spectroscopy (CARS) microscopy. In the near-term, planned work will have a heavy focus on the development and demonstration of a new bioimaging approach based upon vibrational coherence lifetime imaging through a CARS microscopy approach.

Significant effort in ultrafast pulse shaping to optimize the desired nonlinear interaction is expected. Initial experiments will focus on resolving DNA lifecycle events during viral infection of

E. Coli and other canonical bacterial hosts. While this postdoctoral appointee will work extensively on the optical microscopy approach, the successful candidate will be a member of a larger team including genetic biologists and physical chemists.

Collaborate with researchers on customization of ultrafast, chirped pulse optical microscopy experiments utilizing state-of-the-art CARS microscopy approaches.

Collaborate with Sandia biologists to coordinate sample preparation.

Iterate on experimental design to increase the bioimaging contrast provided by vibrational coherence lifetime imaging.

Build optical pulse shaping and chirping components on the laser table, and incorporate into the microscope platform.

You will be expected to partner with a multi-investigator team, present results at national/international meetings, and publish research in high profile peer-reviewed journals.

Due to the nature of the work, the selected applicant must be able to work onsite.

PhD degree in physics, chemistry, biology, optics, engineering or a closely related discipline

Significant experience with ultrafast nonlinear spectroscopy

Solid background in nonlinear optics, instrumentation, ultrafast lasers, and electronics

Solid background in nonlinear optical microscopy for biological applications

Ability to address complex problems creatively, and to work effectively both independently and in collaboration with other researchers.

Strong record of publications in peer-reviewed journals and presentations at scientific conferences

Experience with LabVIEW, MATLAB, SIMION, and 3D CAD

The Gas Phase Chemical Physics Department is part of Sandia's Combustion Research Facility (CRF) in Livermore, California, where over 100 scientists, engineers, and technologists…