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Remote Principal Research Scientist - Organic Synthesis

Remote / Online - Candidates ideally in
Randburg, Johannesburg, 2000, South Africa
Listing for: Placements24
Remote/Work from Home position Listed on 2026-11-11

Job Description & How to Apply Below

Location: Randburg

About the Role

Our client, a world-renowned leader in scientific innovation, is seeking an accomplished Principal Research Scientist specializing in Organic Synthesis to join their esteemed, fully remote research and development division. This pivotal role is designed for an individual with a deep passion for creative problem-solving and a proven history of designing and executing complex synthetic routes. You will be instrumental in advancing our drug discovery programs by synthesizing novel chemical entities and developing innovative synthetic methodologies.

This position offers a unique opportunity to work collaboratively with a global team of experts, contributing significantly to groundbreaking scientific research from the convenience of your home office. We seek a candidate with exceptional technical skills, a robust understanding of reaction mechanisms, and a commitment to scientific excellence.

Key Responsibilities
  • Design and implement novel, efficient, and scalable synthetic routes for complex organic molecules, including drug candidates.
  • Conduct thorough literature reviews to identify and adapt state-of-the-art synthetic methodologies.
  • Perform extensive laboratory synthesis, purification, and characterization of target compounds using advanced analytical techniques (NMR, MS, HPLC, etc.).
  • Troubleshoot challenging synthetic problems and optimize reaction conditions to maximize yield and purity.
  • Collaborate effectively with medicinal chemists, biologists, and other researchers to advance project goals.
  • Maintain meticulous experimental records and prepare detailed reports and presentations of research findings.
  • Contribute to the development of intellectual property through invention disclosures and patent applications.
  • Mentor junior scientists and provide technical guidance on synthetic chemistry challenges.
  • Stay current with emerging trends and technologies in organic synthesis and medicinal chemistry.
  • Ensure adherence to all safety protocols and best laboratory practices in a remote R&D setting.
Requirements
  • PhD in Organic Chemistry or a closely related field.
  • A minimum of 8 years of post-doctoral research experience, with a significant focus on organic synthesis and drug discovery.
  • Demonstrated expertise in multi-step synthesis, asymmetric synthesis, and modern catalytic methods.
  • Proficiency in purification techniques (chromatography) and advanced analytical characterization (NMR, MS).
  • Proven ability to independently design and execute complex synthetic projects.
  • Excellent problem-solving skills and a creative approach to synthetic challenges.
  • Strong written and verbal communication skills, with the ability to present scientific data effectively in a remote environment.
  • Demonstrated leadership potential and experience mentoring junior researchers.
  • A strong publication record in peer-reviewed journals is highly desirable.
  • A passion for scientific innovation and a commitment to advancing human health.
Benefits
  • This role offers a highly competitive salary and a comprehensive benefits package, including substantial annual bonuses, excellent health and wellness coverage, and a robust retirement savings plan.
  • We provide exceptional opportunities for professional growth, including funding for conferences, workshops, and advanced training.
  • As a fully remote position, you will benefit from unparalleled flexibility and work-life integration.

Join our leading scientific organization and contribute to transformative research from anywhere in the world.

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