Post Doctorate Fellow, Medicinal Chemistry

Post Doctorate Fellow, Medicinal Chemistry

Job Category
:
Research - Ionis

Requisition Number
: IONIS
003836

Posted:
November 26, 2025

Full-Time

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have defined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

Postdoctoral Fellow –Nucleosides/Oligonucleotides Medicinal Chemistry

SUMMARY:

We are looking for a motivated and creative scientist to join our Medicinal Chemistry team, focused on the novel nucleosides and oligonucleotides for ASO- and siRNA-based therapeutics. The successful candidate will be highly skilled in synthetic organic chemistry and work at the interface of synthetic chemistry and oligonucleotide drug technology and discovery. The selected candidate will work alongside a talented team of synthetic and computational chemists, biochemists, biologists and pharmacologists to help discover the next generation of nucleosides and oligonucleotides for ASOs and siRNAs programs.

RESPONSIBILITIES:

• Design, execute and troubleshoot synthetic organic chemistry routes relevant to the postdoctoral project
• Analyze and interpret results, and present at internal meetings and scientific conferences
• Writing original research manuscripts for scientific publication(s)

REQUIREMENTS:

• Possess a Ph.D. in synthetic organic chemistry/nucleic acid chemistry, or related fields with 0-3 years of postgraduate training
• Demonstrated expertise to plan and execute multi-step synthesis of complex molecules
• Experienced in modern chromatographic and analytical techniques like TLC, column chromatography, HPLC and NMR to purify and characterize organic compounds
• A track record of scientific excellence and productivity as evidenced by high quality publications
• Strong interpersonal and communication skills
• Ability to manage multiple assignments effectively in a quickly evolving environment
• Ability to be productive and successful in an intense work environment
• Have a passion and enthusiasm for working at the cutting-edge of science
• Required to be full-time onsite at Carlsbad, CA

Please visit our website,  for more information about Ionis and to apply for this position; reference requisition # IONIS
003836

Ionis offers an excellent benefits package! Follow this link for more details:
Ionis Benefits

The pay scale for this position is $65,000 to $87,000

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Equal Opportunity Employer. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.