Faculty Position: Cancer In Vivo Gene Editing Investigators

Job-:
Jacksonville, FL, United States

Schedule:

Full time Posted:
Hours / Pay Period: 80

Benefits Eligible:
Yes Remote worker: 100% On-Site Schedule Details:
Days Union Job:
No

Area of Interest 1:
Cancer Center Marketing Category 1:
Scientist International Assignment:
No

Up to two positions may be filled, with appointments based at either Mayo Clinic Florida or Mayo Clinic Rochester. Position Description The Mayo Clinic Comprehensive Cancer Center (MCCCC) enterprise sites in Jacksonville, Florida and Rochester, Minnesota invite applications for open-rank faculty positions for innovative and accomplished In Vivo Gene Editing Investigators (Physicians and Scientists) to expand in vivo gene editing efforts in the Mayo Clinic In Vivo Human Gene Editing Program (Precision Genomics: Interventional Therapeutics: PG:IT) and the Mayo Clinic Comprehensive Cancer Center’s Programs in Cell Therapy Discovery and Translational Science.

These reflect Mayo Clinic and Mayo Clinic Comprehensive Cancer Center’s commitment to accelerating the next generation of engineered cell therapies and to advancing curative treatments for cancer and other diseases.

We seek exceptional investigators (scientists and physicians) with expertise in in vivo genome engineering and gene editing technologies (e.g., CRISPR/Cas systems, base editing, prime editing, epigenome editing, RNA editing, synthetic gene circuits, or related platforms) applied to human cells for ultimate therapeutic development and intervention. Successful candidates will have the opportunity to play a central role in advancing a rapidly growing, multidisciplinary cell therapy program focused on discovery science, translational innovation, and clinical impact.

A key component of this role will be close collaboration with established CAR-T and immune cell therapy scientists, leveraging advanced genetic editing strategies to enhance persistence, safety, resistance to exhaustion, efficacy, tumor microenvironment adaptation, and manufacturability. While the successful candidates will focus on applications in cancer, they will have the opportunity to work in oncology and non-oncology indications across the Mayo Clinic enterprise to develop novel gene-engineered approaches that expand the therapeutic reach of cellular therapies beyond cancer, including autoimmune, inflammatory, genetic, and other degenerative disorders.

Strategic Role and Leadership Expectations The Gene Editing Scientist will:

Provide scientific expertise and have the opportunity for leadership roles in genome engineering strategies.

Partner closely with CAR-T investigators and translational immunotherapy teams to develop next-generation engineered immune cell platforms.

Develop innovative gene editing solutions to improve efficacy, durability, safety switches, multiplex editing strategies, and precision targeting in both malignant and non-malignant disease settings.

Build scalable and clinically translatable genetic engineering pipelines that accelerate progression from discovery to early-phase clinical trials.

Contribute to the strategic growth and national visibility of the Mayo Clinic PG:

IT Program and Mayo Clinic Comprehensive Cancer Center’s Cell Therapy Programs.

Mentor trainees, junior faculty, and research staff within a collaborative and inclusive academic environment.

Participate in institutional initiatives aligned with Mayo Clinic and Mayo Clinic Comprehensive Cance Center’s vision to Cure, Connect, and Transform healthcare through transformative science.

The successful candidate will be a key driver in integrating advanced genome engineering technologies into existing and emerging cell therapy platforms, enabling novel approaches to immune cell engineering, stem cell modification, in vivo…