Director, Head of Global Procurement

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle® molecules attractive candidates for drug development.

The company is evaluating nuzafatide pevedotin (formerly BT5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; a pipeline of Bicycle® Radio conjugates (BRCs) and imaging agents; zelenectide pevedotin (formerly BT8009), a BDC® targeting Nectin-4, a well-validated tumor antigen; and, through various partnerships, the use of Bicycle®technology to develop therapies to treat diseases in a range of therapeutic areas.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous
  . We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission
  . You can’t change the world if you don’t have determination.
• We are One Team
  . We only succeed when we work together.

WORKING CLASSIFICATION:

At Bicycle, we benefit from a hybrid style working arrangement, allowing our employees where possible the opportunity to collaborate and engage with their coworkers in person while also benefiting from the flexibility of remote working. A typical hybrid arrangement for this role is 3 days onsite per week at our Cambridge, UK office, with the remainder of your working week remote.

With our plans for continued pipeline advancement and organizational scale, we are seeking a Director, Head of Global Procurement. Sitting within the Finance department and reporting to the CFO, this leader will be highly visible and play a critical role in standardizing and leading our global procurement processes, driving cost efficiency, and managing organizational spend with a specific and immediate focus on Clinical Research Organization (CRO) costs, clinical trial spend, and other external R&D costs.

By establishing best-in-class processes and building strong partnerships with key functions like Clinical Operations, R&D, Finance, Legal and IT, you will drive significant value, cost-efficiency, and supply security, directly enabling our continued growth and pipeline advancement.

The ideal candidate will be a passionate, strategic, and experienced procurement leader who can take charge of our global spend, implement best-in-class procurement practices, and collaborate closely with Clinical Operations, R&D, CMC, Legal, IT, and Finance. This successful candidate will drive supply/service security, cost-efficiency, and supplier compliance, ensuring that Bicycle’s external investments are optimized to support our growth.

Strategic Sourcing

• Lead and execute end to end global procurement strategies and processes across the company, prioritizing high-value areas such as clinical development, CMC, specialty labs, and R&D service providers.
• Partner with various teams (e.g. Clinical Operations, CMC, R&D, Legal, Quality, IT) to design and execute RFP/RFI processes for outsourced work.
• Evaluate system requirements to streamline operations for growth and scale.
• Implement risk assessment and mitigation initiatives, including dual-sourcing or multi-sourcing strategies where appropriate.
• Establish, formalize, and lead a comprehensive key vendor management and supplier relationship management framework to drive accountability and high performance across the supply base.
• Design, manage, and continuously improve the supplier evaluation and management process, ensuring operational, quality, and financial performance metrics are met.

Contract Negotiation & Management

• Lead contract negotiations, including Master Service Agreements (MSAs), Statements of Work…