Computational Biologist

Job Title: Computational Biology Scientist, Antibody Engineering
Location: Rockville, MD (100% Onsite)
Hours/

Schedule:

Monday–Friday, 9:00 AM – 5:00 PM
Compensation: $45.00 – $70.00/hour
Type: Contract (6 months, extension possible but not guaranteed)

Leading biotechnology organization focused on cancer therapeutics is seeking a Computational Biology Scientist, Antibody Engineering to support next-generation antibody discovery. This is a highly impactful, first-of-its-kind role within the organization, working at the intersection of structural biology, computational modeling, and AI-enabled protein engineering.

• Develop and apply computational methods to engineer monoclonal and bispecific antibodies (90% computational/10% bench work)
• Integrate deep-learning and physics-based models for protein structure prediction and develop ability assessment
• Analyze structural biology and NGS datasets to guide antibody library design and optimization
• Build and maintain Python-based bioinformatics and machine learning workflows for data processing and modeling
• Collaborate closely with experimental scientists to translate computational insights into actionable design decisions
• Perform limited bench-based molecular biology work, including cloning and experimental support (up to 10%)

• Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Sciences, Computational Biology, Bioengineering, Machine Learning, Computer Science, or related field with 0–3 years postdoctoral experience OR Master’s degree with 5+ years of relevant industry experience
• Strong background in structural biology, including peer-reviewed publications
• Hands-on experience with protein modeling and structure prediction tools such as Alpha Fold, Rosetta Fold, Schrödinger, MOE, or RF diffusion
• Advanced Python programming skills for data analysis, automation, and ML workflow integration
• Experience with NGS data analysis and bioinformatics pipelines
• Familiarity with AI/ML approaches in protein engineering preferred but not required if structural biology and Python expertise are strong
• Ability to work effectively in highly collaborative, interdisciplinary research teams
• Must be legally authorized to work in the United States for any employer

System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.