Radiochemistry Technologist

Overview

Are you looking for a role that challenges you to apply your radiochemistry skills in meaningful, hands‑on ways? Can you see yourself developing and testing innovative radiopharmaceuticals through radiolabeling, formulation, analytical work, and preclinical studies that directly support cutting‑edge therapeutic advancements? Do you thrive in an environment where you collaborate closely with experienced scientists to deliver high‑impact commercial R&D that strengthens Canada’s progress in safe, targeted radiotherapeutics?

If you answered yes, this Radiochemistry Technologist role at Chalk River Laboratories may be the perfect fit—apply today!

• Acquiring in‑depth knowledge of laboratory procedures, instrumental methods, and current advancements in the field.
• Preparing and executing experimental protocols for radionuclide production, separation, purification, radiolabeling, stability studies, analytical method development, in vitro testing, in vivo studies, and small‑animal imaging.
• Performing conjugation chemistry (e.g., DOTA, Macropa), radiolabeling various vectors with radionuclides (Ac‑225, Lu‑177, Ga‑68), and conducting stability testing in biological matrices.
• Carrying out detailed radio chemical analyses (Radio‑TLC, Radio‑HPLC, ICP‑MS, gamma counting) and preparing clear data analysis reports.
• Setting up, calibrating, operating, and maintaining specialized equipment, including dose calibrators, gamma/alpha spectrometers, HPLC, TLC readers, ICP‑MS, and automated synthesis modules.
• Calibrating, operating, and maintaining standard laboratory equipment, including balances, centrifuges, water purification systems, pipettes, pH meters, and UV‑visible spectrometers.
• Using equipment‑control software and developing customized spreadsheets for calculations and reporting.
• Developing, modifying, updating, and following Standard Operating Procedures (SOPs).
• Preparing chemical solutions, maintaining chemical inventory, and overseeing proper management of chemical and radioactive waste.
• Analyzing experimental results and contributing to internal and external summary reports.
• Maintaining accurate and organized laboratory notes.
• Following CNL’s S&T QA Programs and preparing QA documentation, including reporting non‑conformances.
• Applying equipment and procedures creatively and documenting innovative approaches.
• Sourcing equipment from new vendors and navigating procurement processes.
• Collaborating effectively with team members and coordinating shared activities.
• Ensuring compliance with laboratory and facility regulations and requirements.
• Other duties as assigned by your manager.

• Education
  • Graduation from a recognized institute of advanced technology, or equivalent formal education in radiochemistry, inorganic chemistry, analytical chemistry, forensics, biochemistry, chemical engineering technology with three (3) to five (5) years of pertinent experience, OR;
  • Secondary School Graduation Diploma or equivalent, and five (5) to ten (10) years of pertinent and progressive experience or the equivalent in experience, additional education and/or training.
• Experience
  • 3‑5 years of relevant hands‑on work experience in a radiochemistry laboratory is preferred.
  • Experience working with radioactive compounds (quantification, identification, separation, purification, radiolabeling) is a significant asset.
  • Experience performing R&D or production work in engineered enclosures (fume hoods, glove boxes, hot cells) is an asset.
  • Experience in keeping laboratory notebooks, electronic data, and physical records under a research or production Quality Management System.
  • Experience in preparing experimental procedures and technical reports.
  • Experience with conjugation and radiolabeling chemistry of a range of isotopes is desirable.
  • Experience with chemical separation techniques for metal ions, including co‑precipitation, column chromatography, and solvent extraction, is desirable.
  • Experience with radiation detectors, gamma‑ and alpha‑spectrometers, liquid scintillation counters, and similar radiation‑counting equipment is desirable.
  • Experience with in vitro cell culture, techniques and assays, and assets.
  • E…