Medicinal Chemistry Scale-up Research Scientist

Position Summary

The Research Scientist will play a key role in the Medicinal Chemistry Scale‑Up Group, working with a high degree of independence to synthesize small‑molecule drug candidates and intermediates on scales ranging from multi‑grams to hundreds of grams for evaluation. The role requires advanced experimental troubleshooting, process optimisation and the ability to execute complex experimental procedures. The successful candidate will demonstrate resourcefulness, self‑sufficiency and the ability to design alternative approaches to achieve desired outcomes.

Staying current with scientific literature and integrating new methodologies into research activities will be essential.

Design and execute experimental synthetic work to deliver materials on scales ranging from tens to hundreds of grams for local project teams.

Independently develop, optimise and scale up synthetic processes to meet project requirements.

Work collaboratively within the Scale‑Up Group to ensure the rapid delivery of materials.

Share knowledge, troubleshoot challenges and contribute to the continuous improvement of group processes.

Systematically collate, analyse and interpret complex data to generate cohesive conclusions and actionable recommendations for project decisions.

Prepare and deliver detailed study presentations, clearly communicating experimental findings and conclusions.

Stay updated with relevant scientific literature and incorporate new insights into research activities. Identify and evaluate and implement emerging technologies to enhance existing platforms and maintain a competitive edge. Explore and validate novel experimental approaches and scientific principles to achieve project goals.

Demonstrate a diligent approach to process safety and hazard assessment. Ensure all experimental work adheres to safety protocols and regulatory standards.

Contribute significantly to the preparation of patents and/or publications.

• A minimum of a Good Honours degree in Chemistry (BSc or MSc level).
• A PhD or post‑doctoral experience in a relevant area of research, or equivalent industrial experience.

• Proven experience in a large‑scale synthetic laboratory, delivering small molecule organic compounds.
• Proficiency in working with large‑scale glassware (5L to 20L) and a flexible approach to working on a variety of scales.
• Strong synthetic chemistry expertise with a deep mechanistic understanding of reaction pathways.
• Demonstrated ability to perform advanced experimental troubleshooting and process optimisation.
• Familiarity with process safety and hazard assessment, with a meticulous approach to safety practices.
• Strong interpersonal and communication skills, with a collaborative and team‑oriented mindset.
• Experience in identifying and implementing emerging technologies to advance research capabilities.

On‑Site Designated

In this On‑Site designated role, you will work five days per week on‑site with ad hoc flexibility.

Note:

The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, colour, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at A