Senior Scientist; Neurodegeneration ISOgenix Scientist

About ISOgenix

We are an Oxford University spin‑out developing breakthrough therapies for the treatment of ALS and other neurodegenerative diseases. Our approach builds upon novel protein isoform insights identified using our state‑of‑the‑art technologies including long read sequencing and proprietary bioinformatics pipelines. Our founding team has decades of experience in the field of precision medicines, and we have an unwavering focus on developing novel therapies for patients.

We are based in Oxford, UK ( ).

We’re looking for a highly talented and motivated Senior Scientist to join us. In addition to possessing highly relevant expertise, the successful applicant will share our passion for groundbreaking science and be keen to work in a small but growing biotechnology team. They will work collaboratively, openly and be keen to take on new responsibilities as our science progresses and business grows.

As a Senior Scientist, you will play a central role in driving our genetic therapy programs for neurodegenerative diseases.

Key responsibilities will include:

• Leading the design, development, and optimisation of experimental strategies and functional assays to validate transcriptomic targets, assess gene and protein expression, target engagement, and therapeutic efficacy in disease‑relevant models, with approximately 80% of time dedicated to hands‑on, bench‑based experimental execution.
• Providing scientific leadership and critical input into experimental planning, data interpretation, and decision‑making across discovery and early development programs.
• Collaborating closely with cross‑functional teams, including bioinformatics, R&D, and external academic or industry partners, to integrate computational and experimental insights and troubleshoot complex scientific challenges.
• Overseeing the organisation, analysis, and interpretation of internal research data, translating findings into clear insights that inform program direction, portfolio strategy, and business decisions.
• Mentoring junior scientists, including helping set objectives, providing feedback, and helping deliver high‑quality, reproducible data.
• Supporting the identification and evaluation of external opportunities by reviewing and analysing scientific literature, public datasets, and industry developments relevant to neurodegeneration and RNA‑based therapeutics.
• Contributing to the establishment and maintenance of best practices in data quality, documentation, confidentiality, and secure handling of proprietary research information.

To excel in this role, you should possess the following qualifications and skills:

• PhD in Medical Biology, Molecular Biology, Biotechnology, Genetics, Neuroscience, or a related discipline, with substantial relevant experience in academia or industry (industry experience preferred).
• Expertise in genetic therapy development for Amyotrophic Lateral Sclerosis (ALS).
• Proven track record of scientific success, progression, and innovation in therapeutic research, with current hands‑on experimental involvement.
• Demonstrated ability to independently design, develop and validate functional assays, including gene and protein expression assays and disease‑relevant therapeutic efficacy assays, with significant hands‑on experience at the bench.
• Highly organised and meticulous, with a strong commitment to data integrity, experimental reproducibility, and high‑quality documentation.
• Excellent problem‑solving and critical thinking skills, with the ability to manage multiple priorities in parallel, meet deadlines, and drive projects forward while contributing to strategic decision‑making.
• Experience mentoring or managing scientific staff, with a demonstrated ability to motivate and help them successfully meet goals.
• Strong understanding of neurodegeneration‑focused scientific literature, research methodologies, and clinical data, with familiarity with public databases such as Pub Med, Clinical Trials.gov, and relevant gene therapy or genetic disease databases.
• Excellent written, verbal, and presentation skills, with the ability to communicate complex scientific concepts clearly.
• Expertise…