Principal Research Scientist , Immunobiology

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience – and products and services in our Allergan Aesthetics portfolio.

• Principal Research Scientist I, Immunobiology
• Oxford, United Kingdom
• Full-time (onsite)

DJS-Abb Vie is an Abb Vie R&D hub located in Oxford, created following Abb Vie’s acquisition in 2022 of DJS Antibodies. As part of Abb Vie, we aim to develop new medicines that improve the lives of patients with immunological diseases.

To achieve this, we have built and are now expanding an R&D presence in Oxford that integrates drug design, human‑centric biology and mechanistic clinical testing. We have discovered and developed multiple novel pipeline candidates in immunological diseases through our onsite capabilities in antibody discovery and translational biology. We also act as a UK and European hub for the wider Abb Vie R&D organisation, uncovering novel biology and advancing late‑stage assets to the clinic through collaboration with top‑tier academic and biotech partners in Oxford and beyond.

This hub model has already delivered several first‑in‑class drug candidates and clinical assets, supported by a broad network of local collaborations spanning drug discovery technologies, novel disease biology, and innovative clinical trial approaches. The breadth of innovative activity taking place here makes this a unique place to work and a vital part of Abb Vie’s ambition to turn science into cures.

The role reports into the most senior immuno‑biologist on site in Oxford (the Principal Scientist II, Immunobiology). The purpose of the wider Oxford Immunobiology group is to uncover and validate novel biology and targets coming from external academic collaborators, as well as internal ‘reverse translation’ clinical sample datasets, and ensure that the best targets are translated into new discovery programs. Within this larger team, you will line‑manage a new‑build team of 2–3 scientists and associate scientists.

The team will have a particular focus on modelling immunological mechanisms, including the use of complex in vitro model systems (CIVMs). You will need to set strategy around which models the team builds, working with stakeholders across the wider US‑based R&D and Immunology organisation to determine where the organisational need lies. You will also need to work closely with your lab‑based team and peers to optimise and troubleshoot the models, and therefore require strong working knowledge of key immunological techniques, and standards of scientific rigour required to establish robust assays/models.

You will work closely with your boss and peers to develop the medium and long strategy for immunobiology in Oxford, defining priority biology areas and targets. You will also shape and lead the generation of data packages to support target entry into the Abb Vie Immunology portfolio.

• Line manage a group of 2–3 scientists and associate scientists working on modelling immunobiological processes.
• Engage with the literature and attend conferences to maintain deep understanding of target and disease biology.
• Set the strategy for this team, identifying the key biological areas and mechanisms for the team to focus on.
• Work closely with benchtop scientists to design experiments and troubleshoot model builds.
• Spend a portion of time leading and working from the bench, establishing and understanding the models owned by the team.
• Identify and evaluate new technologies and equipment to expand capabilities in line with current and future needs.
• Shape and lead the generation of target validation packages to support the entry of targets into the Abb Vie portfolio.
• Support later stage discovery programs by uncovering the biological mode of action of leads and candidate drugs.
• Develop a deep understanding of Abb Vie Immunology’s research strategy.
• Validate tools to support pathway deconvolution and target…