Principal Scientist, Bioanalytical & Molecular Assays

Overview

Joining Moderna means advancing mRNA science to transform medicine. Work with exceptional global teams on a broad pipeline and build a career that makes a real difference for patients. This role is based at Moderna’s Harwell site and offers the opportunity to shape the future of molecular and genomic biomarker strategies across a diverse clinical portfolio. Working at the intersection of molecular biology, bioanalysis, genomics, informatics, and clinical development, you will play a critical role in advancing programs from discovery through clinical development while helping translate clinical insights into future pipeline opportunities.

• Provide hands‑on scientific leadership and laboratory support for the design, development, optimization, and delivery of fit‑for‑purpose molecular assays supporting clinical endpoints.
• Lead the development and implementation of RT‑qPCR, dPCR, and NGS‑based assays across a broad range of applications, including gene expression, viral load analysis, mRNA pharmacokinetics, bulk RNA sequencing, targeted RNA sequencing, single‑cell RNA sequencing, TCR/BCR repertoire profiling, targeted DNA panels, and pathogen or viral sequencing.
• Own end‑to‑end assay lifecycle activities, including method development, qualification, validation, and technology transfer to internal laboratories and external CRO partners.
• Author and review validation plans, reports, protocols, acceptance criteria, and supporting technical documentation in accordance with GCLP requirements and industry best practices.
• Ensure assays are scientifically robust, reproducible, scalable, and aligned with clinical program objectives and regulatory expectations.
• Oversee phase‑appropriate clinical sample testing activities, ensuring rigorous quality control, quality assurance, data integrity, and operational excellence throughout assay execution.
• Lead deviation investigations, CAPA activities, and inspection‑readiness efforts to support compliance and audit preparedness.
• Serve as a scientific subject matter expert for molecular assay strategies across multiple clinical development programs spanning Phase 1 through Phase 3.
• Work independently while providing matrix leadership across multidisciplinary teams of molecular biologists, NGS scientists, and bioinformaticians.
• Mentor colleagues and contribute to the continued development of scientific capabilities across the organization.
• Partner closely with Clinical Development, Biomarkers and Translational Medicine, Bioanalytics, Regulatory Affairs, Quality Assurance, and Data and IT teams to ensure alignment between assay strategies and broader program goals.
• Integrate basic science research, bioanalytical approaches, genomics, and informatics to support clinical development decisions and generate actionable biological insights.
• Reverse‑engineer clinical findings to identify novel scientific opportunities that can inform and strengthen Moderna’s future pipeline.
• Effectively communicate scientific strategies, project plans, risks, challenges, and study outcomes to both technical and non‑technical stakeholders.
• Influence cross‑functional decision‑making by translating complex molecular and genomic data into clear, actionable recommendations.
• Contribute to the adoption of innovative technologies, advanced computational approaches, and AI‑enabled solutions that enhance assay development, data interpretation, and translational research capabilities.
• Thrive within a fast‑moving, highly collaborative environment where scientific rigor, innovation, and patient impact remain central to every decision.

• We obsess over learning. We don’t have to be the smartest we have to learn the fastest.
• We act with dynamic range, driving strategy and execution at the same time at every step.

• Ph.D. in Molecular Biology, Genomics, or related field with 9+ years of biotech/pharma experience (or M.S. with 12+ years of directly relevant experience).
• Deep, hands‑on experience developing and validating clinical qPCR, dPCR, and NGS assays and managing end‑to‑end workflows from method development, validation, sample testing and reporting.
• Strong knowledge of…