Senior Scientist

Senior Scientist — Oxford

On-site — Start-up Biotechnology Company

Talentmark is partnering with a biotech start-up developing next-generation gene therapies for severe genetic diseases. The company is advancing cutting-edge preclinical programmes with a highly collaborative scientific team and innovative platform technologies, aiming to deliver transformative therapies to patients with high unmet need.

This is a site-based position located  role involves scientific leadership, CRO oversight, and hands-on laboratory work in a fast-paced, science-driven environment.

You will drive preclinical in vivo studies through external CRO partnerships, supporting progression of gene therapy programmes from discovery through translational development. The successful candidate will manage CROs, oversee in vivo studies, and contribute hands-on wet-lab work while collaborating cross-functionally within a biotech setting.

• Lead the design, oversight, and interpretation of preclinical in vivo studies with external CRO partners
• Manage CRO relationships across study planning, timelines, budgets, protocol review, and data delivery
• Act as the internal scientific lead for animal model studies including efficacy, biodistribution, and toxicology
• Maintain hands-on involvement in molecular and cellular biology workflows
• Support the design and optimisation of gene expression constructs and vector development activities
• Contribute to data analysis, project planning, and scientific reporting across multiple programmes

• PhD in Molecular Biology, Gene Therapy, Immunology, Virology, Translational Medicine, or related discipline
• Proven biotech industry experience within preclinical or translational research environments
• Strong track record managing CRO-based in vivo studies
• Experience with histology, bioanalysis, or biodistribution studies
• Experience driving study execution to timelines
• Hands-on wet lab expertise in molecular and/or cell biology
• Strong scientific data interpretation and problem-solving skills
• Excellent project management abilities

• Experience with in gene therapy, viral vectors, or advanced therapeutics
• Exposure to GLP toxicology or IND-enabling studies
• Background working with translational animal models

Entitlement to work in the UK is essential. Please quote the job reference in all correspondence.