Principal Research Scientist , Novel Therapeutics

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

• Principal Research Scientist I, Novel Therapeutics
• Oxford, United Kingdom
• Full-time (onsite)

At DJS-Abb Vie, we are advancing novel therapeutics and translating immunological science into innovative R&D programmes with the potential to make a meaningful difference for patients. As a UK-based discovery hub within Abb Vie Immunology, we combine the focus and agility of a specialist team with the resources and ambition of a global pharmaceutical company.

We are now entering an exciting phase of team growth and scientific progression in Oxford. To support this next stage, we are seeking an experienced and highly capable drug hunter to join us as Principal Research Scientist I within our existing Novel Therapeutics - Cellular Depletion Team.

This role offers the opportunity to contribute to work that is scientifically ambitious, strategically important, and directly connected to patient impact. You will help shape programmes that aim to deplete pathogenic cells and enable long‑term disease modification, while working in an environment that values scientific ownership, deep expertise, and collaborative problem‑solving.

In this role, you will have significant scope to shape scientific strategy, influence portfolio direction, and act as molecule lead on selected programmes where appropriate. You will work closely with the team leader and cross‑functional partners to define approaches, assess risk, and guide experimental plans. We are looking for someone who is confident taking ownership of complex scientific challenges and who thrives when given the freedom to lead with rigour and initiative.

In this role, you will have significant scope to shape scientific strategy, influence portfolio direction, and act as molecule lead on selected programmes where appropriate. You will work closely with the team leader and cross‑functional partners to define approaches, assess risk, and guide experimental plans. We are looking for someone who is confident taking ownership of complex scientific challenges and who thrives when given the freedom to lead with rigour and initiative.

This role is ideal for a scientist who wants to deepen and apply expertise in drug discovery and immunology focusing on cellular depletion via any available modalities. You will have the opportunity to tackle challenging discovery questions and complex protein designs, contribute original ideas and champion innovative methods ultimately enhancing the scientific capability within the team. You will also mentor colleagues, share knowledge, and help develop a strong drug discovery mindset across the function.

Our work is driven by the goal of delivering better outcomes for patients with serious and challenging diseases. In this role, you will help advance novel therapeutics with the potential to achieve durable disease improvement beyond symptomatic treatment. Your contributions will support programme progression from concept to candidate nomination, influence translational strategy, and help shape the future of our discovery portfolio.

• Where appropriate act as molecule lead on pipeline programmes, providing technical expertise and cross‑functional leadership as teams form around assets
• Together with the team leader develop and deliver drug discovery strategy in alignment with Abb Vies overall immunology strategy
• Serve as a key lab focused scientist at the DJS-Abb Vie Oxford site, and ultimately act as a recognised scientific expert within the wider Abb Vie R&D organisation in your specialist mechanism of action
• Collaborate with colleagues across immunology…