Scientist - Functional Genomics, Immunology

Scientist – Target Validation Immunology // Oxford

You are an innovative immunologist with experience validating novel therapeutic targets in primary immune cell systems. You enjoy designing and executing mechanistic experiments, applying gene-editing technologies, and generating robust biological evidence that drives drug discovery decisions.

We are partnering with an exciting Oxford-based biotech combining human genetics, immunology, and drug discovery to identify and validate novel targets for the treatment of immune-mediated diseases. Their work sits at the intersection of cutting-edge target discovery and translational biology, with strong momentum across multiple programmes.

THE ROLE:

As a Scientist, Target Validation Immunology, you will be responsible for designing and executing experiments to validate genetically-supported targets in clinically relevant immune cell systems. This is a highly hands-on role, focused on translating biological hypotheses into compelling datasets through the use of primary human immune cells, functional immunology assays, and CRISPR-based perturbation approaches.

Working closely with genetics, computational biology, and drug discovery teams, you will play a key role in determining which targets progress into the pipeline. This position offers the opportunity to contribute directly to high-value programme decisions while developing deep expertise in translational immunology and target validation.

Key Responsibilities:

• Apply CRISPR-based approaches (knockout, knockdown, and gene modulation) to investigate target biology and mechanism of action
• Develop and run functional immunology assays, including immune activation, differentiation, cytokine profiling, proliferation, and cell-cell interaction studies
• Work across a range of immune cell types, including T cells, NK cells, monocytes, macrophages, and other primary immune populations

ABOUT YOU:

• PhD or equivalent industry experience in Immunology, Cell Biology, Functional Genomics, or a related discipline
• Strong hands-on experience working with primary human immune cells
• Experience applying CRISPR technologies to investigate gene function and validate therapeutic hypotheses

LOGISTICS:

• Location: Oxford (on-site)
• Employment: Permanent

If you're excited by translating human biology into therapeutic opportunities and using primary immune cell and CRISPR-based approaches to validate the next generation of drug targets, we'd love to hear from you.