Senior Bioinformatician - Target Discovery

If you're a bioinformatician with an interest in the commercial side of drug discovery and the ability to provide scientific leadership within a collaborative team, this role offers the opportunity to contribute to OBT's proteomics-based target discovery efforts and help drive the development of innovative therapeutics.

Oxford Biotherapeutics (OBT) is a clinical-stage biotechnology company developing innovative antibody-based therapeutics for the treatment of cancer. You will contribute directly to the pre-clinical development of our immuno-oncology pipeline.

Our proprietary OGAP® platform, the world’s largest cancer-specific membrane protein library, enables the discovery of novel, highly tumour‑specific antigens for first‑in‑class ADC, Bispecific T-cell Engager (BITE®), and CAR‑based therapeutics. Our lead asset, OBT
076, is in Phase 1b clinical development, supported by a strong internal and partnered pipeline with leaders such as Roche, GSK, Bristol Myers Squibb, Boehringer Ingelheim, and Zymeworks.

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Reporting to the Senior Vice President, Bioinformatics and Information Systems in Bioinformatics, you will oversee the mining and annotation of OBT's proprietary proteomics dataset to identify and research candidate targets for cancer therapeutics. This will involve interfacing with the commercial team, scoping incoming questions, timelines, and turning analysis into answers that support partnering and portfolio decisions.

This role will suit someone who works well at pace and is energised by commercial conversations as well as by the science. A sound computational background is expected, but the role places greater emphasis on organisation, judgement and communication than on method development.

The position is office-based at the Oxford Science Park, supporting close daily collaboration with the scientific and commercial teams, with occasional travel.

• Attend and contribute to business and partnering discussions, following up on the analysis they generate.
• Scope and deliver analyses in response to requests from colleagues across the business, maintaining a clear view of the team's commitments.
• Prepare and present analysis summaries and supporting materials for internal decision‑making and external partner discussions.

• Manage the bioinformatics target discovery activity: plan, prioritise and direct the mining and annotation of OBT's proprietary proteomics dataset to identify and verify candidate targets for therapeutic programmes.
• Provide the analysis and recommendations that inform target selection and prioritisation.
• Carry out hands‑on analysis where needed to support the team.

• Oversee the quality, consistency and reproducibility of the target annotation produced by the team, ensuring that conclusions are clearly evidenced and traceable to the underlying data.
• Maintain and improve the standard workflows, templates and documentation.

• Supervise target mining and annotation.
• Collaborate across the Bioinformatics team and with cross‑functional colleagues to support company goals.

• Master's degree or PhD in bioinformatics, computational biology, or a related life science discipline.
• 5+ years of relevant experience in bioinformatics or computational biology, in industry or academia.

• Knowledge of cancer biology and targeted cancer therapeutics.
• Experience with proteomics, particularly mass spectrometry‑based proteomics.
• Familiarity with protein annotation and expression resources.

• Proficiency in Python and R,…