Principal or Senior in vitro Disease Biologist

Category:
Research

Location:

Oxford, South East, GB

Your impact starts here

As Principal or Senior in vitro Disease Biologist, you will turn complex human biology into clear insights that guide drug discovery decisions. Working in the Target Identification & Maturation team, you will drive translational science that connects cardiometabolic disease understanding, human-relevant models and multi-modal data to the discovery and progression of new drug targets and molecules.

What you’ll bring

We are looking for an experienced in vitro scientist who can combine disease area, experimental, and analytical expertise to generate robust evidence and guide decision‑making for drug discovery. You will bring scientific and technical depth, sound judgement and the ability to influence effectively in a collaborative, global research environment.

• A PhD or Master's degree in Metabolic or Cardiovascular biology, Biochemistry, Cell and Molecular Biology, Pharmacology, or a related discipline.
• Experience in an industry drug discovery, translational research or biotechnology setting.
• Demonstrated experience in developing translational human cell‑based cardiometabolic disease models, incorporating functional, imaging and omics‑based experimental readouts
• Experience in developing automation‑friendly functional genomics‑ and chemical‑based experimental screening workflows, applying Design of Experiment (DoE) principles, and generating reproducible high‑quality FAIR data and outputs.
• Strong capability in integrating and interpreting multi‑modal data to support target discovery, molecule characterisation and project decisions, including hands‑on use of digital/AI tools.
• A track record of leading scientific projects, influencing cross‑functional stakeholders, communicating complex findings and mentoring colleagues.
• Experience in novel drug target diligence and evidence package generation is desirable.

You can distinguish robust, decision‑relevant evidence from exploratory findings and communicate conclusions clearly to both technical and non‑technical audiences. You build trusted relationships, remain curious about emerging science and actively contribute to high scientific standards.

What you’ll do

As Principal or Senior in vitro Disease Biologist, you will help shape scientific strategy and translate biological hypotheses into practical discovery approaches. Working with a high degree of independence, you will combine disease area, experimental, and analytical expertise to generate robust evidence, influence decisions and advance our discovery pipeline.

Your key responsibilities will include:

• Applying your knowledge of cardiometabolic physiology and disease pathophysiology to identify innovative human‑relevant opportunities for drug target and molecule discovery.
• Designing and implementing translational human cell‑based cardiometabolic disease models, incorporating functional, imaging and omics‑based experimental readouts.
• Developing automation‑friendly functional genomics‑and chemical‑based experimental screening workflows, applying Design of Experiment (DoE) principles, and generating reproducible high‑quality FAIR data and outputs.
• Integrating in vitro functional, imaging and multi‑omics outputs with other data types - including in vivo, ex vivo, human genetics, clinical and real‑world datasets - using appropriate digital and AI tools, to identify targets, mechanisms and translational signals.
• Leading drug target diligence, developing evidence‑based target profiles and presenting clear recommendations that support selection, prioritisation and pipeline progression.

You will also collaborate across scientific disciplines and with external partners, communicate the confidence and limitations of findings, and help colleagues…