Principal Scientist, Functional Genomics

As Principal Scientist, Functional Genomics, you will combine cutting-edge biology, gene editing, and advanced screening approaches to uncover new therapeutic opportunities. You will develop and apply innovative, automation-friendly functional genomics capabilities, using automation and digital approaches to scale data generation and accelerate target identification and validation for progression to Novo’s research portfolio.

You are a scientifically accomplished and collaborative researcher with deep expertise in functional genomics and a proven ability to influence research strategy, technology development and scientific outcomes. You combine technical excellence with strong stakeholder engagement and leadership skills.

• A PhD or Master’s degree in Molecular Biology, Biochemistry, Cell Biology, or a related scientific discipline.
• Typically, 7 to 10 years of pharmaceutical or biotechnology industry experience, with demonstrated expertise in functional genomics applied to target identification and validation.
• Extensive experience developing and leading functional genomics and cell-based screening workflows, including gene editing, cell engineering, and advanced in vitro model systems.
• Strong knowledge of experimental design and statistical approaches, along with expertise in applying automation and digital tools to assay development and screening (e.g., automation-ready assay design, scalable workflows, data capture/processing, and analytics), and the ability to generate impactful scientific insights through robust data interpretation is essential.
• Strong understanding of target classes and ability to design mechanistic studies that elucidate target biology and mode of action.
• Proven ability to mentor colleagues, build strategic collaborations, and effectively communicate complex scientific concepts to multidisciplinary stakeholders.

Experience working with external partners, driving technology adoption, and advancing FAIR (Findable, Accessible, Interoperable, Reusable) data practices in a research environment would be highly advantageous.

As Principal Scientist in the Functional Genomics team, you will serve as a scientific leader, driving the development and implementation of advanced experimental approaches and the adoption of automation technologies and digital applications to scale data generation in support of TIM’s target discovery. You will work across multidisciplinary teams to establish innovative, automation-amenable in vitro assays, generate high-quality decision-making data, and help shape the future direction of functional genomics capabilities for screening within TIM.

You will also mentor colleagues, influence scientific strategy, and build collaborations that enhance research impact.

Your responsibilities will include:

• Driving the development and implementation of innovative functional genomics, gene-editing, cell engineering and assay technology strategies using advanced cell and molecular biology approaches to support target identification and validation.
• Leading the design and execution of mechanistic studies to establish target biology, mode of action and therapeutic relevance enabling robust target validation and maturation.
• Advancing and standardizing the analysis, interpretation, and integration of complex multi-omic datasets and translating findings into actionable recommendations that support target selection and project progression.
• Exploring and strengthening collaborations with internal stakeholders, academic institutions, biotechnology partners, and external service providers to expand scientific capabilities and accelerate discovery efforts.
• Mentorin…