Bioinformatician

Department of Paediatrics, Sanders Research Group, Institute of Developmental & Regenerative Medicine IDRM, Old Road Campus, Oxford

We have an exciting opportunity to join the Sanders Group and the Medical Research Council Centre of Research Excellence (MRC CoRE) in Therapeutic Genomics. The programme aims to advance the understanding, diagnosis, and treatment of rare genetic neurodevelopmental disorders including autism, through genomic research and the development of genome-targeted therapies, such as CRISPR-based editing and antisense oligonucleotides (ASOs). This three-year position aims to revolutionise how therapies are identified, developed, and brought to the clinic for rare genetic disorders.

The Senior Bioinformatician, based within the Department of Paediatrics, will provide critical technical and analytical support for a range of different projects across the Sanders Group and MRC CoRE. The postholder will be responsible for the analysis, management, and interpretation of large-scale genomic datasets, ensuring the development and maintenance of robust, reproducible bioinformatics pipelines. Working across both the Sanders Group and the MRC CoRE, you will collaborate with researchers to define analytical strategies, provide expert statistical input, and identify new projects that contribute to the overall goals of the research programme.

The role is based within the Department of Paediatrics, part of the University of Oxford’s Medical Sciences Division, and is located at the Institute of Developmental & Regenerative Medicine (IDRM). The postholder will work closely with Professor Stephan Sanders and a multidisciplinary team including data managers, developers, and international colleagues at the University of California, San Francisco (UCSF). You will be part of a team of outstanding international experts and industry partners committed to priming the clinical landscape for the next generation of genetic medicines.

This position is offered full-time on a fixed-term contract for an initial period of two years.

The Department of Paediatrics is committed to equality and valuing diversity. The Department of Paediatrics has been honoured with the Athena Swan Gold award, a national gender equality charter, recognising the Department's innovative policies and practices. We are committed to the professional development of our staff by providing up to ten paid days annually for skill enhancement and allowing applications for additional training funding.

By joining us, you will have the opportunity to contribute to a forward-thinking department.

We welcome new staff with ideas who are willing to shape the future of the department that thinks about its staff and wellbeing. In addition to the University of Oxford wellbeing resources , the Department of Paediatrics sponsors weekly exercise classes such as yoga and bootcamp sessions as well as a choir. For staff on work visas, we also offer financial assistance towards visa renewal fees.

These activities are designed to promote physical and mental wellbeing among staff members.

Please visit our website to find out more about the Department.

You will be educated to degree level in Bioinformatics, Computational Biology, Genomics, Computer Science, or a related discipline, or possess equivalent relevant experience. You will have substantial experience analysing and interpreting large-scale genomic datasets, including high-throughput sequencing data, using established bioinformatics tools and workflows. You will demonstrate expertise in developing and maintaining reproducible bioinformatics pipelines, with proficiency in scripting languages such as Python and/or R, workflow management systems (e.g.…