Scientist, Research Scientist, Immunology Research

Nucleome Therapeutics is a growing biopharmaceutical company discovering first-in-class antibody therapeutics for inflammatory and autoimmune diseases. Our proprietary 3D genomics platform combines laboratory science and machine learning to uncover disease mechanisms and therapeutic targets from human genetic variation in the non-coding genome.

Founded by University of Oxford gene-regulation experts and backed by leading life-science investors, we bring together genomics, immunology, drug discovery, data science and software development. We value scientific rigour, creativity, smart risk-taking and an inclusive culture that empowers people to make a difference.

As a Scientist in Drug Discovery, you will develop cellular assays and perform experiments to validate therapeutic targets and investigate the pharmacology and mechanism of action of tool and candidate molecules for immune-mediated and autoimmune diseases. With senior scientific guidance and study objectives and priorities agreed with your supervisor, you will execute defined studies, troubleshoot experimental challenges and deliver high-quality data to support early biologics programmes, collaborating across multidisciplinary teams and communicating findings at project and functional meetings.

• Experimental delivery:
  Contribute to experimental design and optimise and execute reproducible cellular immunology and pharmacology studies under senior scientific guidance, supporting target validation and early drug discovery.
• Assay development:
  Develop cell-based assays using primary immune cells and cell lines, including multiparameter flow cytometry and immune-response characterisation assays.
• Mechanistic insight:
  Evaluate therapeutic hypotheses and characterise the on-target and off-target biological effects of tool and candidate molecules.
• Data analysis:
  Analyse and interpret experimental data with appropriate attention to sensitivity, reproducibility and scientific quality.
• Communication:
  Summarise and present results, conclusions and recommendations clearly to specialist and non-specialist colleagues.
• Collaboration:
  
  Work effectively within cross-functional project teams, contribute to scientific discussions and help troubleshoot experimental challenges.
• Documentation:
  Maintain accurate experimental records and uphold data integrity to support project continuity and decision-making.

• PhD in immunology, cellular biology, pharmacology or a related discipline, or equivalent relevant experience in a small biopharmaceutical environment.
• Strong understanding of cellular immunology and pharmacology, particularly in immune-mediated disease biology.
• Practical experience handling primary immune cells and developing or running downstream cellular assays.
• Hands-on experience with multiparameter flow cytometry and associated analysis tools, such as Flow Jo.
• Experience optimising cellular assays for reproducibility, sensitivity and fitness for purpose.
• Experience with plate-based immunoassays or fluorescence assays; familiarity with multiplex platforms such as Luminex or MSD is advantageous.
• Confidence analysing, visualising and presenting data using tools such as Graph Pad Prism.
• Demonstrated ability to execute and analyse agreed experiments independently, with guidance on experimental design and interpretation available from senior colleagues.

• Clear written and verbal communication, including the ability to explain complex ideas to specialist and non-specialist audiences.
• Ability to work independently on agreed tasks, seek guidance when needed and contribute positively to a multidisciplinary team.
• Strong organisation and…