VP, Program Management

Overview

Summit Therapeutics Inc. is a biopharmaceutical oncology company focused on improving quality of life and resolving unmet medical needs. Summit values integrity, passion for excellence, purposeful urgency, collaboration, and a commitment to people. The team is dedicated to advancing clinical studies in oncology.

Summit has multiple global Phase 3 clinical studies in oncology, including non-small cell lung cancer (NSCLC) programs and other oncology indications. Ivonescimab is an investigational therapy not presently approved by regulatory authorities other than China’s NMPA. Summit is headquartered in Miami, Florida with additional offices in California, New Jersey, the UK, and Ireland.

The Vice President, Program Management reports to the Chief Business & Strategy Officer and will lead the cross-functional program management team to maximize the value of Summit s pipeline drug candidates, with a focus on SMT
112 (ivonescimab). The role drives the execution of development plans across multiple clinical trials (including Phase III) toward BLA/MAA and other regulatory filings and commercialization. The VP PM is accountable for establishing and maintaining an integrated project plan covering all aspects of the SMT
112 development program.

• Establish and maintain the integrated SMT
  112 program plan through cross-functional leadership to create and execute a development strategy that maximizes development, regulatory, and commercial success.
• Integrate input from all functional areas to identify development and commercialization issues and the strategic approach to resolve each issue, including timelines, deliverables, and tradeoffs.
• Lead cross-functional discussions to reach decisions, including overcoming challenges when full consensus cannot be reached.
• Document key decisions and produce documentation appropriate for the Executive Committee, along with detailed plans to support timelines and tasks.
• Report and present program information to the Executive Committee, functional heads, and other stakeholders.
• Drive decision-making for SMT
  112 development toward marketing approval and lifecycle strategy, incorporating relevant research, analysis, and competitive data.
• Challenge cross-functional representatives to ensure issues are addressed and functional input meets program objectives.
• Manage internal/external development complexity, identify risks, and lead contingency planning and problem solving.
• Ensure development and implementation of optimal clinical, regulatory, and medical affairs strategies to protect and maximize asset value.
• Ensure adequate project resource utilization and budget management with clarity on changes and tradeoffs.
• Mentor, coach, and develop team members; ensure alignment with the Executive Committee on Go/No-Go decisions, timelines, activities, resources, budgets, valuations, and prioritization.
• Drive strategic alignment across development, research, regulatory, and medical affairs; focus on portfolio value and appropriate Go/No-Go decisions.
• Other duties as assigned.

• Experience with drug development in oncology is required.
• Bachelors degree required; advanced degree (MBA, MS, PhD, Pharm
  
  D) strongly preferred.
• 12 years of experience in program management or similar function within biopharmaceuticals or life sciences required.
• Experience in late-stage drug development and registration preferred.
• Experience in cross-functional team leadership including strategy development and delivery of programs.
• Prior experience in pre-commercial or early commercial biotech/pharma strongly preferred.
• Proven ability to translate complex data into executive-ready insights.
• Expertise in project management and process improvement methodologies (PMP, Lean Six Sigma, Agile).
• Strong analytical mindset and change leadership in fast-paced environments; ability to collaborate cross-functionally and influence stakeholders.

The pay range for this role is $285,000–$330,000 annually. Actual compensation is based on factors including skill set, depth of experience, certifications, and location. Total compensation may include bonus, stock, benefits, and other variable components.

Summit does not accept referrals from employment businesses/agencies for vacancies posted on this site. All employment agencies must contact Summit s Talent Acquisition team for authorization before referring candidates.

Required Experience: Exec

This description reflects current expectations and may be amended as Summit grows and adapts to business needs.