Scientist I​/Scientist II, Translational Biology

Scientist I / Scientist II, Translational Biology

Palo Alto, CA

Gondola Bio is a collection of biopharmaceutical companies focused on developing next-generation therapeutics for genetic diseases. Originally carved out of Bridge Bio, Gondola Bio secured $300M in private financing from external investors in 2024 and became an independent company within the Bridge Bio ecosystem. Gondola Bio aims to leverage cutting‑edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases.

Neurofibromatosis Type 1 (NF1), a genetic condition where tumors grow on the nerves and skin, is the focus of a pre‑clinical stage program in Gondola Bio’s portfolio. NF1 affects multiple organ systems, with a wide range of manifestations ranging from neurofibromas (benign nerve sheath tumors) that carry the risk of malignant transformation, to learning difficulties and bone abnormalities. Despite having two FDA‑approved MEK inhibitors for NF1 patients, there is still a huge unmet need in providing safer and more efficacious treatment options to the NF1 patients, and Gondola Bio strives to address this gap.

We seek an entrepreneurial research scientist to drive the biology and translational research for NF1 Therapeutics. You will be supporting strategy and direction, assay development, mouse model experimentation, preclinical dose guidance, regulatory document writing including INDs, and other translational biology and pharmacology experiments through a combination of internal and external efforts. This job requires excellent communication and interpersonal skills as well as technical and scientific abilities.

We hope to hear from you.

• Design and perform studies critical for biomarker discovery and validation using techniques like cell culture, PCR, ELISA, Western blotting, flow cytometry, and genetic engineering.
• Support critical translational studies that further elucidate the mechanism and biology for the NF1 drug candidates
• Manage relationships with CROs for efficient execution of all the preclinical and translational studies
• Collaborate with cross‑functional teams, including DMPK, toxicology, clinical development, regulatory to advance our therapeutic candidates through clinical development in a fast‑paced, dynamic environment
• Maintain meticulous lab notebooks, write reports, and potentially contribute to regulatory documents (e.g., INDs), publications, or patents.
• Contribute to due diligence and gap analysis on potential new Gondola Bio assets
• Develop new research methods and protocols

• Ph.D. in Molecular Biology, Biochemistry, or related discipline or M.S. with 3+ years hand‑on experience in the lab.
• Proficient in molecular biology techniques, statistical analysis, data interpretation, and operating lab equipment.
• Strong problem‑solving skills, attention to detail, and teamwork.
• Experience working with cell lines in tissue cultures, running western blots and cell‑based assays.
• Ability to work in a fast‑paced environment
• Strong scientific background and achievements in bioscience and translational medicine, ideally demonstrated by scientific publications, presentations, and/or patents
• Proven track record of successfully working in research programs
• Strong understanding of drug discovery and development processes
• Excellent communication (written & verbal) and organizational skills
• Ability to think strategically and execute experiments effectively
• Experience in collaborating with cross‑functional teams and external partners
• Knowledge of basic regulatory requirements and industry standards
• Demonstrate creative 'out of the box' thinking to solve complex technical problems and champion innovative technologies to achieve project goals
• Commitment, drive, and ownership mindset

• Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
• A culture inspired by our values: put patients first; think independently; be radically transparent; every minute counts; and let the science speak
• Collaborative business environment
• Excellent compensation package (Base, Performance Bonus, Equity)
• Excellent benefits package
• Flexible PTO
• A fast‑paced, data‑driven, work environment with world‑class R&D minds and capabilities
• Work with the most productive groups of R&D operators in the industry
• A platform for meaningful scientific contributions to shine

The base pay range for this position is $100,000 to $140,000 per year. The actual compensation offered will be determined based on a number of job‑related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.