Antibody and Protein Engineering Platform Head

Antibody and Protein Engineering Platform Head

Responsibilities:

• Proficient in the full process of antibody discovery, guiding antibody screening platforms (e.g., hybridoma, single B-cell, display platforms) for antibody selection.
• Responsible for antibody and protein engineering modifications, including humanization, affinity maturation, de‑immunization, stability optimization, Fc engineering, and cytokine modifications.
• Lead the design and molecular optimization of bispecific and multispecific antibody formats, ensuring expression levels, develop ability, immunogenicity, and pharmacokinetic properties meet downstream development requirements.
• Conduct high‑throughput expression of antibodies and proteins, along with early‑stage develop ability testing and physicochemical characterization.
• Collaborate closely with cross‑functional teams (e.g., functional biology, pharmacology) to advance project progress.
• Provide strategic recommendations at internal project reviews and leadership meetings.
• Track cutting‑edge technologies (e.g., AI‑assisted antibody discovery, novel antibody development) to continuously optimize and upgrade the R&D platform.

Qualifications:

• Education and Major
  :
  Ph.D. in Molecular Biology, Structural Biology, Genetic Engineering, Bioengineering, Biopharmaceuticals, or related fields.
• Professional Knowledge
  :
  Expertise in antibody development techniques, including hybridoma, phage/yeast display, molecular cloning, protein expression and purification, and affinity maturation, with a focus on antibody engineering.
• Work Experience
  :
• Minimum 10 years of industrial R&D experience in antibody discovery or protein engineering, with a preference for candidates who have successfully led projects to PCC and clinical stages.
• Overseas background, especially experience in multinational pharmaceutical companies, is preferred.
• Experience in managing teams of 30+ members, with strong adaptability and problem‑solving skills in high‑pressure, fast‑changing environments.
• Proficiency in antibody and protein structural analysis, with hands‑on experience in designing and optimizing bispecific and multispecific antibodies.
• Deep understanding of antibody structure‑function relationships, sequence optimization, and expression/purification workflows.
• Familiarity with antibody develop ability and immunogenicity assessment, Fc engineering, and half‑life extension strategies.

Skills:

• Excellent research capabilities, demonstrated by patents or scientific achievements.
• Proficiency in English as a working language.

Other Requirements:

• Strong team management and leadership abilities.
• Ability to adapt quickly and handle complex tasks under pressure and rapid changes.

Seniority level:
Director

Employment type:

Full‑time

Job function:
Science

Industries:
Pharmaceutical Manufacturing