Senior Manager – Accounting

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH.

Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration.

To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. We are seeking a Senior Manager, Accounting to join our finance team. The ideal candidate will have a strong fundamental understanding of U.S. GAAP and experience managing general ledger accounting and financial close activities. Experience with in the pharmaceutical, biotechnology, or life sciences industry is strongly preferred.

The Senior Manager, Accounting will play a key role in overseeing the monthly, quarterly, and annual close process and ensuring the accuracy, completeness, and integrity of the Company’s financial records. This position will oversee accounting activities across several areas, including cash, investments, fixed assets, prepaid expenses, accruals, leases, and equity. The Senior Manager will perform primary-level reviews of journal entries and account reconciliations, support the Company’s SOX compliance program, and partner with internal and external stakeholders on accounting and audit matters.

This leadership role will also partner with our Financial Systems and Operations team to support our broader finance data strategy and will work collaboratively with Chief Accounting Officer’s leadership team to enable process optimization and global financial process ownership for the record to report cycle.

The successful candidate will possess strong leadership capabilities, exceptional organizational skills, and excellent written and verbal communication skills. This individual will also be responsible for developing and mentoring members of the accounting team while supporting special projects, and other strategic initiatives.

• Manage assigned aspects of the monthly, quarterly, and annual general ledger close process, ensuring activities are completed accurately and in accordance with established deadlines.
• Oversee accounting activities for areas including cash, investments, fixed assets, prepaid expenses, accruals, leases, and equity.
• Perform primary-level review of journal entries, account reconciliations, supporting schedules, and accounting analyses to ensure accuracy, completeness, appropriate supporting documentation, and compliance with U.S. GAAP and Company policies.
• Maintain a strong understanding of assigned balance sheet and income statement accounts and proactively identify unusual activity, reconciling items, trends, and accounting matters requiring further analysis.
• Oversee and support the execution and documentation of SOX controls and assist in enhancing internal controls and procedures to ensure compliance with SOX requirements and Company policies.
• Support internal and external audit activities, including preparation and review…